{"id":"W4409951953","doi":"10.1038/s42255-025-01295-w","title":"GIPR-Ab/GLP-1 peptide–antibody conjugate requires brain GIPR and GLP-1R for additive weight loss in obese mice","year":2025,"lang":"en","type":"article","venue":"Nature Metabolism","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute","funders":"CIHR Skin Research Training Centre; Canadian Institutes of Health Research; Banting and Best Diabetes Centre, University of Toronto; Novo Nordisk; Government of Canada; Amgen","keywords":"Internal medicine; Endocrinology; Conjugate; Peptide; Glucagon-like peptide-1; Obesity; Weight loss; Body weight; Medicine; Chemistry; Diabetes mellitus; Biochemistry; Mathematics; Type 2 diabetes","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003441519,0.001082018,0.0008328786,0.0009289826,0.0002845934,0.000572786,0.0006862889,0.0008414549,0.002905619],"category_scores_gemma":[0.0001742746,0.0005740216,0.0007516196,0.0003292761,0.0007522537,0.0007039416,0.0004160191,0.002555691,0.001234014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004436524,"about_ca_system_score_gemma":0.0004914759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000677457,"about_ca_topic_score_gemma":0.001243675,"domain_scores_codex":[0.9994457,0.0000614491,0.00007144241,0.0001282912,0.0001547003,0.0001384386],"domain_scores_gemma":[0.9996787,0.00002496017,0.0001164809,0.00003227868,0.00002548702,0.000122059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006967562,0.0002192071,0.00006187543,0.00004157453,0.00001184218,0.00004768994,0.00001404662,0.0000381222,0.9976867,0.0001125994,0.00006301812,0.001006581],"study_design_scores_gemma":[0.0003368465,0.00281037,0.003129907,0.00002607968,0.00007077438,0.0004292819,0.000055746,0.0007772715,0.9894075,0.0001225653,0.002816152,0.00001750182],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874644,0.001254619,0.006446326,0.0004751142,0.0001368111,0.0001563767,0.001317062,0.0005172364,0.002231987],"genre_scores_gemma":[0.9596754,0.003358137,0.01643253,0.0006511496,0.0001261527,0.0007568888,0.003661527,0.0005069125,0.01483124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002905619,"threshold_uncertainty_score":0.009720206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004978346049369487,"score_gpt":0.2958500834012905,"score_spread":0.290871737351921,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}