{"id":"W4409963258","doi":"10.1056/nejmoa2413181","title":"Mepolizumab to Prevent Exacerbations of COPD with an Eosinophilic Phenotype","year":2025,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Chronic Obstructive Pulmonary Disease (COPD) Research","field":"Medicine","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"GlaxoSmithKline","keywords":"Mepolizumab; COPD; Medicine; Phenotype; Eosinophilic; Immunology; Eosinophil; Internal medicine; Pathology; Biology; Genetics; Asthma; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005292766,0.0001636461,0.0005913371,0.000523565,0.00005203111,0.000006175097,0.0002007274,0.00005227498,0.0005533366],"category_scores_gemma":[0.0004583588,0.0001045494,0.00006433795,0.0006249989,0.0001796154,0.0001041895,0.00003955798,0.0003484909,0.000003726174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002407086,"about_ca_system_score_gemma":0.001388157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002079337,"about_ca_topic_score_gemma":0.00008424703,"domain_scores_codex":[0.9980643,0.0001194111,0.0005764126,0.0001854124,0.0008062196,0.0002482139],"domain_scores_gemma":[0.9979602,0.0001724457,0.0002077423,0.0003610532,0.0006617039,0.0006368646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.02559008,0.002956865,0.05159311,0.001911118,0.001818646,0.001394904,0.005960123,0.0008099892,0.03351928,0.008305909,0.037619,0.828521],"study_design_scores_gemma":[0.1492543,0.02145025,0.6945753,0.008507608,0.00257834,0.002407355,0.002712118,0.0005804252,0.006480761,0.006828735,0.1041455,0.0004793089],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9639055,0.003916697,0.001599562,0.02168037,0.0003264886,0.0005876572,0.000008971915,0.00001550996,0.007959269],"genre_scores_gemma":[0.9941711,0.0001478272,0.001259905,0.0004706656,0.001414256,0.000003913618,0.00001016812,0.00001970708,0.002502423],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8280417,"threshold_uncertainty_score":0.6058648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01774998384450298,"score_gpt":0.3190168330179998,"score_spread":0.3012668491734968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}