{"id":"W4409967622","doi":"10.1093/nar/gkaf347","title":"PRMT5 promotes full-length <i>HTT</i> expression by repressing multiple proximal intronic polyadenylation sites","year":2025,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research; Structural Genomics Consortium; McMaster University; Hospital for Sick Children; Université de Montréal; BC Children's Hospital; University of Toronto; Institute for Research in Immunology and Cancer; SickKids Foundation; University of British Columbia; Lunenfeld-Tanenbaum Research Institute; Princess Margaret Cancer Centre","funders":"National Institute of General Medical Sciences; Janssen Biotech; Canadian Institutes of Health Research; Bristol-Myers Squibb Canada; National Institutes of Health; Mitacs; Ontario Genomics Institute; Stand Up To Cancer Canada; Genentech; Government of Ontario; Ontario Institute for Cancer Research; Structural Genomics Consortium; Merck KGaA; Genome Canada; Irma T. Hirschl Trust; American Association for Cancer Research; Bayer; Takeda Pharmaceuticals U.S.A.; Pfizer; Entertainment Industry Foundation; Boehringer Ingelheim; Genentech Foundation","keywords":"Huntingtin; Polyadenylation; Biology; RNA splicing; Exon; Intron; Trinucleotide repeat expansion; Alternative splicing; RNA-binding protein; Messenger RNA; Molecular biology; Precursor mRNA; Cell biology; Genetics; RNA; Gene; Allele","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007516065,0.0001967807,0.0001729549,0.0001902033,0.0004168078,0.000133354,0.0003390106,0.0003978765,0.00006683866],"category_scores_gemma":[0.000633426,0.0001925003,0.00008320766,0.0004571303,0.0002197972,0.00002529305,0.0004233548,0.0004406515,0.00002426976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001571123,"about_ca_system_score_gemma":0.0002558221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003225361,"about_ca_topic_score_gemma":0.00003153116,"domain_scores_codex":[0.9975274,0.0003177401,0.0003219732,0.0007380902,0.0005120652,0.000582762],"domain_scores_gemma":[0.9987578,0.00006954738,0.00008708198,0.0006732363,0.0003116758,0.0001006448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003470675,0.00009723991,0.0042312,0.00005560605,0.00003650395,7.695859e-7,0.00008519882,0.0001044587,0.9545324,0.00002416112,0.02354655,0.01693883],"study_design_scores_gemma":[0.0009510972,0.0002831096,0.002383259,0.0001281383,0.0000116202,0.000004847485,0.00009430182,0.006092387,0.9588267,0.000168283,0.03085575,0.0002005303],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904076,0.00369149,0.002410992,0.0009327668,0.0001252735,0.0008081355,0.00002114046,0.00005940189,0.00154315],"genre_scores_gemma":[0.9942787,0.0001781491,0.001143761,0.00003688254,0.0003187134,0.0001113552,0.0003631121,0.00004232359,0.003526961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0167383,"threshold_uncertainty_score":0.7849933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01845413970114626,"score_gpt":0.3212494201760036,"score_spread":0.3027952804748574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}