{"id":"W4409978758","doi":"10.1016/j.reprotox.2025.108928","title":"Exposure to brominated flame retardants during pregnancy and lactation increases the prevalence of breast lesions and cancer-associated pathways in sprague-dawley rats","year":2025,"lang":"en","type":"article","venue":"Reproductive Toxicology","topic":"Toxic Organic Pollutants Impact","field":"Environmental Science","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Canada; Institut National de la Recherche Scientifique","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Armand-Frappier Foundation; Cancer Research Society; Canadian Institutes of Health Research; Institut de Recherche Clinique De Montréal","keywords":"Lactation; Pregnancy; Breast cancer; Breast milk; Cancer; Physiology; Medicine; Brominated flame retardant; Internal medicine; Endocrinology; Obstetrics; Chemistry; Biology; Fire retardant; Organic chemistry; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003484052,0.0001531989,0.0002455157,0.00008876214,0.0001168408,0.00001088038,0.0001706749,0.00009667101,0.0001395187],"category_scores_gemma":[0.001344804,0.0001239146,0.00001888358,0.0005694748,0.0003269155,0.0001793146,0.0002906287,0.0001602042,0.000003901544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003102472,"about_ca_system_score_gemma":0.00006308866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005443673,"about_ca_topic_score_gemma":0.001262246,"domain_scores_codex":[0.9983318,0.000338837,0.0002809819,0.000617066,0.0001391937,0.0002920748],"domain_scores_gemma":[0.9992529,0.0001634148,0.0001513788,0.0003519123,0.00001114602,0.00006929897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001076821,0.0001523847,0.2270651,0.0000449443,0.00002613299,0.00001090618,0.001593086,0.00003538289,0.7409379,0.00001474915,0.00002310827,0.02998864],"study_design_scores_gemma":[0.0003936194,0.0001334626,0.9036702,0.0002632798,0.00003273458,0.00003439849,0.0001852006,0.00002271672,0.09493972,0.0002180245,0.000003831426,0.0001028457],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964323,0.001075558,0.000002803773,0.001414593,0.00008009584,0.000650038,0.000168315,0.00002699482,0.0001492677],"genre_scores_gemma":[0.9989693,0.000439118,0.00004664646,0.00004210724,0.0000132066,0.00003625935,5.721295e-7,0.00001073773,0.0004420743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6766051,"threshold_uncertainty_score":0.505309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01154502894343953,"score_gpt":0.2511910355798007,"score_spread":0.2396460066363612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}