{"id":"W4409980303","doi":"10.1002/cpt.3616","title":"Modeling and Simulation to Inform Apixaban Dosing in Pediatrics With Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma Treated With Asparaginase","year":2025,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Pfizer; Bristol-Myers Squibb","keywords":"Lymphoblastic lymphoma; Lymphoblastic Leukemia; Dosing; Asparaginase; Medicine; Lymphoma; Acute lymphocytic leukemia; Oncology; Pediatrics; Internal medicine; Leukemia; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004422429,0.000377419,0.0007353787,0.0002589288,0.0002374755,0.00004840314,0.0001425281,0.000243374,0.00003183191],"category_scores_gemma":[0.00009407902,0.0002489983,0.00006433569,0.001130604,0.0002764676,0.0001864474,0.0001300621,0.0003997948,0.0000145536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005892998,"about_ca_system_score_gemma":0.0009165919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003466634,"about_ca_topic_score_gemma":0.00003878195,"domain_scores_codex":[0.9977576,0.0001633023,0.0006999184,0.000557202,0.0002528074,0.0005691528],"domain_scores_gemma":[0.9965673,0.002514676,0.0001476556,0.0002046616,0.0002275159,0.0003381594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.1918568,0.003006935,0.1497228,0.0007773025,0.007165371,0.002866471,0.001181992,0.5357407,0.001668671,0.0000512618,0.0006723569,0.1052894],"study_design_scores_gemma":[0.02575501,0.002961056,0.01659287,0.0001966287,0.007128103,0.0001206335,0.0001682996,0.9395385,0.0002718931,0.00002832884,0.006809229,0.0004294784],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865382,0.0005558986,0.006293454,0.005033834,0.0002550943,0.0009177843,0.000008135082,0.00009952683,0.0002980431],"genre_scores_gemma":[0.9625466,0.001850368,0.001038013,0.03407743,0.0001869156,0.00005460229,0.000009320911,0.00003738357,0.0001993403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4037978,"threshold_uncertainty_score":0.9999962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08085524973616941,"score_gpt":0.4362556578160278,"score_spread":0.3554004080798583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}