{"id":"W4409980751","doi":"10.4103/abr.abr_531_23","title":"CAR-T Cell Therapy: Managing Side Effects and Overcoming Challenges","year":2025,"lang":"en","type":"review","venue":"Advanced Biomedical Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"","keywords":"Chimeric antigen receptor; Medicine; Cytokine release syndrome; Side effect (computer science); Clinical trial; Toxicity; Cancer; Intensive care medicine; Immunotherapy; Bioinformatics; Oncology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008830127,0.0007728703,0.001233964,0.001952742,0.0002880476,0.001055846,0.001000563,0.001345672,0.003482173],"category_scores_gemma":[0.0007990981,0.0002437666,0.0005468305,0.001467763,0.0005688274,0.001432573,0.0006566585,0.002677096,0.001752075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007472866,"about_ca_system_score_gemma":0.001073798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008303188,"about_ca_topic_score_gemma":0.001566342,"domain_scores_codex":[0.9997384,0.00005721926,0.00002778021,0.0000349781,0.0001125472,0.0000290921],"domain_scores_gemma":[0.999658,0.0001736597,0.00003968514,0.00001015952,0.00008730153,0.00003120718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005114839,0.00007772498,0.00009338034,0.01094123,0.00005663658,0.0001555252,0.00005333784,0.0004228521,0.00175737,0.005833648,0.03076932,0.9497879],"study_design_scores_gemma":[0.00001904278,0.00009259985,0.0002974787,0.00252072,0.00005256202,0.0008353267,0.00004759065,0.0001228553,0.000541295,0.002216329,0.9932422,0.00001204569],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001383032,0.9977429,0.0002227835,0.0005834748,0.0002244692,0.000005664312,0.00001153854,0.00001156394,0.001059321],"genre_scores_gemma":[0.0007705797,0.9978109,0.0002423581,0.0003406953,0.0001668339,0.00001001712,0.00002396226,0.000002038422,0.0006327075],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003482173,"threshold_uncertainty_score":0.01164901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1062726592849745,"score_gpt":0.4623723882326222,"score_spread":0.3560997289476477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}