{"id":"W4409980907","doi":"10.1016/j.jcyt.2025.03.174","title":"EXTRACELLULAR VESICLES RELEASED FROM ENHANCED ADIPOSE TISSUE-DERIVED MESENCHYMAL STROMAL CELLS POLARIZE MACROPHAGES TOWARDS A DISTINCT IMMUNOMODULATORY PROFILE","year":2025,"lang":"en","type":"article","venue":"Cytotherapy","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Arthritis Society; University of Toronto; University Health Network","funders":"","keywords":"Mesenchymal stem cell; Adipose tissue; Extracellular vesicles; Stromal cell; Extracellular; Cell biology; Microvesicles; Chemistry; Adipose tissue macrophages; Vesicle; Biology; Cancer research; Biochemistry; White adipose tissue; Membrane; Gene; microRNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001896995,0.0004886799,0.0004062974,0.00008965551,0.0002199487,0.0001075518,0.0006822381,0.0003558622,0.0004172172],"category_scores_gemma":[0.0000706808,0.0005070341,0.0002580528,0.0001925855,0.0002946473,0.00001422847,0.0001675911,0.0002448139,0.00006954723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006922441,"about_ca_system_score_gemma":0.0003561791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001819533,"about_ca_topic_score_gemma":0.0000231604,"domain_scores_codex":[0.9974106,0.0002576931,0.0005130944,0.000961257,0.0002756819,0.0005816596],"domain_scores_gemma":[0.9982422,0.00003796199,0.000197454,0.001198001,0.0001192327,0.000205134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007210941,0.0003153829,0.0003795371,0.00003848239,0.0002560526,0.00005394691,0.0001241453,0.00001322193,0.977056,0.00006017423,0.0006844813,0.02029748],"study_design_scores_gemma":[0.002090141,0.0002780136,0.01170845,0.00005408089,0.00007720003,0.000002342111,0.00008502327,0.00009608071,0.975903,0.0003545171,0.008851156,0.000499939],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.947549,0.03242003,0.01770407,0.0001121513,0.0004180805,0.0006675851,0.0003201322,0.00010295,0.0007059393],"genre_scores_gemma":[0.9865555,0.0002519849,0.00688974,0.0002355057,0.0002706322,0.0001046775,0.0004693539,0.0001003467,0.005122332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03900636,"threshold_uncertainty_score":0.9997382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005726100230716139,"score_gpt":0.2465497124153776,"score_spread":0.2408236121846614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}