{"id":"W4409980907","doi":"10.1016/j.jcyt.2025.03.174","title":"EXTRACELLULAR VESICLES RELEASED FROM ENHANCED ADIPOSE TISSUE-DERIVED MESENCHYMAL STROMAL CELLS POLARIZE MACROPHAGES TOWARDS A DISTINCT IMMUNOMODULATORY PROFILE","year":2025,"lang":"en","type":"article","venue":"Cytotherapy","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Arthritis Society; University of Toronto; University Health Network","funders":"","keywords":"Mesenchymal stem cell; Adipose tissue; Extracellular vesicles; Stromal cell; Extracellular; Cell biology; Microvesicles; Chemistry; Adipose tissue macrophages; Vesicle; Biology; Cancer research; Biochemistry; White adipose tissue; Membrane; Gene; microRNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001281149,0.0002265698,0.0001872194,0.0001068294,0.00008804227,0.0002936376,0.00006937124,0.0001954778,0.000951062],"category_scores_gemma":[0.00009500481,0.00007159672,0.0002966659,0.00009894975,0.0001250761,0.0001974258,0.0002010778,0.0002852551,0.0003011321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001201507,"about_ca_system_score_gemma":0.0001288402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001260629,"about_ca_topic_score_gemma":0.00021145,"domain_scores_codex":[0.9998434,0.00002360657,0.00001685499,0.0000298859,0.00004545156,0.00004088457],"domain_scores_gemma":[0.9999286,0.00001333861,0.00001879491,0.000006301308,0.00002080232,0.00001208109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009231481,0.00000923233,0.0003199664,0.00005310119,0.000004294665,0.00006168393,0.00001104035,0.00004187747,0.9982337,0.00007008715,0.0000204405,0.001082317],"study_design_scores_gemma":[0.00001326421,0.0002138632,0.005282995,0.00001446826,0.00002500391,0.0003956486,0.00005283887,0.0003907966,0.9903587,0.00006949792,0.003177697,0.000005270995],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880702,0.003205188,0.006408326,0.0001048428,0.00004188846,0.00003936295,0.0004712996,0.00003485848,0.001624073],"genre_scores_gemma":[0.9926536,0.001494031,0.003636444,0.00008718206,0.00003008834,0.00005000685,0.000524514,0.00001412616,0.001510103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000951062,"threshold_uncertainty_score":0.003181577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005726100230716139,"score_gpt":0.2465497124153776,"score_spread":0.2408236121846614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}