{"id":"W4409980955","doi":"10.1016/j.jcyt.2025.03.180","title":"GENOME EDITING WITH THE DNA-PK INHIBITOR AZD7648 INDUCES A LOW FREQUENCY OF COPY NUMBER VARIATIONS IN HEMATOPOIETIC STEM AND PROGENITORS CELLS","year":2025,"lang":"en","type":"article","venue":"Cytotherapy","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Terry Fox Research Institute; Institute for Research in Immunology and Cancer","funders":"","keywords":"Genome editing; Haematopoiesis; Biology; Stem cell; Progenitor cell; Genome; DNA; Genetics; Computational biology; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002303055,0.0003377375,0.0005140566,0.0003673217,0.0001965185,0.0005229675,0.0003492294,0.0005262869,0.001959231],"category_scores_gemma":[0.0002816042,0.0001956409,0.0002501961,0.0002277773,0.0003198299,0.0001571464,0.0002767417,0.0009640083,0.0005631818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003006333,"about_ca_system_score_gemma":0.0002286701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005390376,"about_ca_topic_score_gemma":0.0006591543,"domain_scores_codex":[0.9995819,0.00005144405,0.00003812337,0.0001232634,0.0001504911,0.00005484694],"domain_scores_gemma":[0.9996771,0.000106767,0.00007730535,0.00006950282,0.00002488644,0.0000443752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000321294,0.00001014776,0.00009241586,0.000009920444,0.000003619304,0.00003363323,0.000006469556,0.00006827249,0.9985585,0.0000935096,0.00003380385,0.001057598],"study_design_scores_gemma":[0.000005141138,0.0000551989,0.0009477302,0.000001299321,0.000006359953,0.0001397899,0.000004341225,0.0004850643,0.9971392,0.00003192228,0.001181709,0.000002234569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9682796,0.001470763,0.02313713,0.000290499,0.00007591637,0.0001000452,0.001181835,0.0009907079,0.004473533],"genre_scores_gemma":[0.9889405,0.000315589,0.004402814,0.00007639192,0.00001200562,0.00004868861,0.0007975988,0.0001200829,0.00528617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001959231,"threshold_uncertainty_score":0.006554306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004062521117845436,"score_gpt":0.2505574513865805,"score_spread":0.246494930268735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}