{"id":"W4409980955","doi":"10.1016/j.jcyt.2025.03.180","title":"GENOME EDITING WITH THE DNA-PK INHIBITOR AZD7648 INDUCES A LOW FREQUENCY OF COPY NUMBER VARIATIONS IN HEMATOPOIETIC STEM AND PROGENITORS CELLS","year":2025,"lang":"en","type":"article","venue":"Cytotherapy","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Terry Fox Research Institute; Institute for Research in Immunology and Cancer","funders":"","keywords":"Genome editing; Haematopoiesis; Biology; Stem cell; Progenitor cell; Genome; DNA; Genetics; Computational biology; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000100894,0.0001069461,0.0001168618,0.00003779004,0.00004300127,0.00001735543,0.00009320948,0.00007779352,0.000008269506],"category_scores_gemma":[0.000003931579,0.00007936803,0.00002686423,0.0001585319,0.00005701523,0.00000297757,0.00002237921,0.00006715512,7.637436e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009096614,"about_ca_system_score_gemma":0.00005524484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001636192,"about_ca_topic_score_gemma":0.00003682709,"domain_scores_codex":[0.9994445,0.0000263639,0.0001543481,0.0001756221,0.00006516105,0.0001339931],"domain_scores_gemma":[0.9996988,0.00001743593,0.0000480602,0.0001743527,0.00003815018,0.00002318604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000137204,0.00003399628,0.009217481,0.0000516801,0.00004677908,0.000001032904,0.0005825342,0.00009257113,0.9894339,0.00009582825,0.00004189444,0.0003886219],"study_design_scores_gemma":[0.0005379347,0.0000699941,0.005425997,0.00005418613,0.00001151387,0.000005290673,0.0004368685,0.00002091873,0.992533,0.00005238774,0.0007414694,0.0001103823],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944126,0.000726751,0.004117482,0.0001516893,0.00008741517,0.0002422124,0.000007602138,0.000006845044,0.0002474111],"genre_scores_gemma":[0.9989645,0.0001050107,0.000572595,0.00006755922,0.0001205767,0.00004381909,0.000005210609,0.00001411125,0.0001065498],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004551976,"threshold_uncertainty_score":0.3236534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004062521117845436,"score_gpt":0.2505574513865805,"score_spread":0.246494930268735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}