{"id":"W4409981033","doi":"10.1016/j.jcyt.2025.03.175","title":"Animal Component- and Extracellular Vesicle-Free Medium Facilitates Isolation and Characterization of Small Extracellular Vesicles from Human Bone Marrow Mesenchymal Stromal Cells","year":2025,"lang":"en","type":"article","venue":"Cytotherapy","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Terry Fox Research Institute; Stemcell Technologies","funders":"","keywords":"Extracellular vesicles; Mesenchymal stem cell; Stromal cell; Extracellular; Human bone; Cell biology; Extracellular vesicle; Bone marrow; Isolation (microbiology); Vesicle; Chemistry; Microvesicles; Biology; In vitro; Biochemistry; Immunology; Membrane; Cancer research; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002853122,0.00030509,0.0002256152,0.0002888228,0.0002468136,0.0004590529,0.0002251202,0.0002893407,0.0007265744],"category_scores_gemma":[0.0002224664,0.000125815,0.0002560181,0.0002339049,0.0002284659,0.0002625555,0.0003242908,0.000401566,0.0003670311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002020714,"about_ca_system_score_gemma":0.0002435419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007160977,"about_ca_topic_score_gemma":0.001189405,"domain_scores_codex":[0.999853,0.00003665919,0.00001484163,0.00002759359,0.00004461012,0.00002329138],"domain_scores_gemma":[0.9999003,0.00003873569,0.00001386327,0.0000181501,0.00001472217,0.00001413906],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005565413,0.000008560907,0.0001060809,0.00001685306,0.000002878447,0.00003340769,0.00001799879,0.00004501606,0.9987212,0.0002486972,0.00001478882,0.0007289263],"study_design_scores_gemma":[0.000009363993,0.00008002648,0.001931116,0.000005771509,0.00001758883,0.0002728903,0.00001685684,0.0005490065,0.9930863,0.00007824614,0.003949344,0.00000344438],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9419359,0.003336477,0.05025454,0.000212035,0.00006541943,0.0001992721,0.0007361944,0.0001142271,0.003145855],"genre_scores_gemma":[0.9771427,0.001238513,0.01637763,0.00006074684,0.00001497868,0.0001400891,0.001830865,0.00007029359,0.003124126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007265744,"threshold_uncertainty_score":0.002430677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009214607778292853,"score_gpt":0.2280407962190449,"score_spread":0.2188261884407521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}