{"id":"W4409981033","doi":"10.1016/j.jcyt.2025.03.175","title":"Animal Component- and Extracellular Vesicle-Free Medium Facilitates Isolation and Characterization of Small Extracellular Vesicles from Human Bone Marrow Mesenchymal Stromal Cells","year":2025,"lang":"en","type":"article","venue":"Cytotherapy","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Terry Fox Research Institute; Stemcell Technologies","funders":"","keywords":"Extracellular vesicles; Mesenchymal stem cell; Stromal cell; Extracellular; Human bone; Cell biology; Extracellular vesicle; Bone marrow; Isolation (microbiology); Vesicle; Chemistry; Microvesicles; Biology; In vitro; Biochemistry; Immunology; Membrane; Cancer research; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002715412,0.0003113594,0.0003362104,0.0001093315,0.0001518785,0.00006230043,0.0002629247,0.0002458391,0.00004739861],"category_scores_gemma":[0.00003142239,0.0003398702,0.00009307494,0.0001051516,0.0003350467,0.0000248261,0.000158866,0.0001266444,0.000001776474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001918703,"about_ca_system_score_gemma":0.00005377434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005012539,"about_ca_topic_score_gemma":0.00001727927,"domain_scores_codex":[0.9981986,0.0001732569,0.0005368711,0.0006240755,0.0001767689,0.0002904657],"domain_scores_gemma":[0.9989008,0.00004418227,0.0002355451,0.0005977436,0.00008862767,0.000133096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003547061,0.0001779613,0.01198974,0.00008323453,0.0001103049,0.00001054601,0.0001990013,0.000003849315,0.9848362,0.0003982462,0.00005990816,0.001776298],"study_design_scores_gemma":[0.001823531,0.0002810386,0.07661618,0.00005495614,0.00006180273,0.000003421823,0.0001325391,0.0007434771,0.9179083,0.0005834491,0.001498865,0.0002924801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810087,0.01237397,0.005539508,0.0002379618,0.00009810492,0.0004138532,0.0002556,0.00003111413,0.00004120762],"genre_scores_gemma":[0.9956772,0.0005348535,0.002421563,0.00006250067,0.000130122,0.00002100046,0.0005668966,0.00004181817,0.0005440699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06692795,"threshold_uncertainty_score":0.9999053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009214607778292853,"score_gpt":0.2280407962190449,"score_spread":0.2188261884407521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}