{"id":"W4409981788","doi":"10.1016/j.jcyt.2025.03.015","title":"SUCCESSFUL REDIRECTION OF TCR SPECIFICITY AGAINST CRYPTIC LEUKEMIA ANTIGENS USING NON-VIRAL TCR ENGINEERING","year":2025,"lang":"en","type":"article","venue":"Cytotherapy","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"T-cell receptor; Biology; Leukemia; Virology; Immunology; Computational biology; T cell; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002166845,0.0004335185,0.0001963586,0.0002920525,0.0002026219,0.0004669772,0.0002479921,0.0003864585,0.001338721],"category_scores_gemma":[0.0002226383,0.0001391497,0.0001898991,0.0001677972,0.0002865706,0.0001859761,0.0003857557,0.0007498037,0.000390844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002557727,"about_ca_system_score_gemma":0.0002142133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002622673,"about_ca_topic_score_gemma":0.0005662414,"domain_scores_codex":[0.9997421,0.00003710878,0.00001646841,0.00005555282,0.00006843854,0.00008035787],"domain_scores_gemma":[0.9998853,0.00003285281,0.00002895481,0.00002170788,0.00001599804,0.00001515737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003940375,0.00002936451,0.00007301562,0.00003038014,0.000002862829,0.00004929932,0.0000214041,0.0001642192,0.9954314,0.0007143937,0.00005835904,0.003385941],"study_design_scores_gemma":[0.000009693163,0.00007498219,0.00017471,0.000002932467,0.000007851492,0.0001437195,0.00000842306,0.0006964394,0.9967624,0.00006161799,0.002055661,0.000001607784],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9384025,0.00169108,0.05018369,0.0002069343,0.0001385281,0.0002021956,0.0001593356,0.0006249357,0.008390721],"genre_scores_gemma":[0.9894105,0.0005367557,0.006805437,0.00006041503,0.00001067123,0.00005346914,0.00007759263,0.00006701188,0.002978142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001338721,"threshold_uncertainty_score":0.004478455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01980362529982406,"score_gpt":0.3108074725585182,"score_spread":0.2910038472586942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}