{"id":"W4409981788","doi":"10.1016/j.jcyt.2025.03.015","title":"SUCCESSFUL REDIRECTION OF TCR SPECIFICITY AGAINST CRYPTIC LEUKEMIA ANTIGENS USING NON-VIRAL TCR ENGINEERING","year":2025,"lang":"en","type":"article","venue":"Cytotherapy","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"T-cell receptor; Biology; Leukemia; Virology; Immunology; Computational biology; T cell; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001841113,0.0001774553,0.0003880401,0.0002849569,0.00009456366,0.00001847819,0.0001197791,0.0001139447,0.0001540371],"category_scores_gemma":[0.00003405415,0.0001553166,0.0001601421,0.0004188476,0.00009758492,0.00007111316,0.00003398294,0.0002696953,0.00001361244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000227509,"about_ca_system_score_gemma":0.0002487421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003296823,"about_ca_topic_score_gemma":0.000006837853,"domain_scores_codex":[0.9987794,0.00002671931,0.0003265714,0.0002570326,0.0002879346,0.0003222967],"domain_scores_gemma":[0.9993875,0.00007443794,0.00006456774,0.0002486426,0.0001326065,0.00009224624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005710274,0.00009624699,0.05416195,0.0003285249,0.0001909946,0.00004351315,0.0001750495,0.0008466339,0.93523,0.0003264674,0.0006604839,0.007369083],"study_design_scores_gemma":[0.002473627,0.0003569076,0.2024071,0.0009125609,0.00006350294,0.000031859,0.0001282934,0.06902368,0.6991543,0.0001458929,0.02493594,0.0003663191],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900145,0.0006820151,0.0030054,0.0002566715,0.000351499,0.0002793056,0.000009900563,0.00004406724,0.005356665],"genre_scores_gemma":[0.9940312,0.0009047323,0.001951094,0.0002340369,0.0003632925,0.000005690027,0.00001412545,0.00002595501,0.00246991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2360757,"threshold_uncertainty_score":0.6333626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01980362529982406,"score_gpt":0.3108074725585182,"score_spread":0.2910038472586942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}