{"id":"W4409982987","doi":"10.1126/scitranslmed.adu7718","title":"Hypoxia-inducible factors link poor glycemic control to diabetic retinopathy","year":2025,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Glycemic; Hypoxia (environmental); Diabetic retinopathy; Medicine; Diabetes mellitus; Retinopathy; Internal medicine; Ophthalmology; Endocrinology; Bioinformatics; Biology; Chemistry; Oxygen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005140243,0.0003800785,0.0004264369,0.0003219809,0.0003253517,0.001463289,0.0002940794,0.001022474,0.003719337],"category_scores_gemma":[0.0007873279,0.0001998648,0.0004190285,0.0002497716,0.0004556802,0.00055999,0.0007240367,0.002326454,0.0006319694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004482449,"about_ca_system_score_gemma":0.0004886781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001347227,"about_ca_topic_score_gemma":0.002463459,"domain_scores_codex":[0.9997459,0.00004744706,0.00001931118,0.00005474008,0.00006864346,0.0000638903],"domain_scores_gemma":[0.9995128,0.00005659943,0.0001767662,0.00002621142,0.0001079739,0.000119647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.005624881,0.0008268816,0.05072581,0.002507322,0.001046903,0.002841575,0.000858424,0.0008640905,0.1792883,0.02223231,0.3152676,0.4179161],"study_design_scores_gemma":[0.0007080454,0.001458144,0.4052362,0.001393644,0.001187833,0.004541288,0.002547553,0.004279637,0.06107023,0.02850627,0.4888535,0.0002177871],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2947514,0.4908843,0.01117638,0.1367014,0.03353211,0.0001204036,0.00343007,0.0005011933,0.02890274],"genre_scores_gemma":[0.7221646,0.2227168,0.002411738,0.01648418,0.01437458,0.00006244516,0.001412195,0.0001061464,0.02026732],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003719337,"threshold_uncertainty_score":0.01244241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01798169929128044,"score_gpt":0.31803621557037,"score_spread":0.3000545162790895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}