{"id":"W4409982990","doi":"10.1186/s13567-025-01521-z","title":"MARCH8 promotes the proteasomal degradation of foot-and-mouth disease virus VP1, VP2, and VP3 to negatively regulate viral replication","year":2025,"lang":"en","type":"article","venue":"Veterinary Research","topic":"Animal Disease Management and Epidemiology","field":"Agricultural and Biological Sciences","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Agriculture","funders":"National Key Research and Development Program of China; National Natural Science Foundation of China","keywords":"Biology; Foot-and-mouth disease virus; Virology; Viral replication; Virus; Replication (statistics); Degradation (telecommunications); Microbiology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001021877,0.0002693862,0.0001377385,0.0001512152,0.0001460198,0.000193972,0.000118303,0.0001634734,0.001042362],"category_scores_gemma":[0.0001302243,0.00007254569,0.0002112646,0.00006955911,0.0001491402,0.0001638533,0.0001774752,0.0002492245,0.0002722423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003274076,"about_ca_system_score_gemma":0.0001245007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000374411,"about_ca_topic_score_gemma":0.0004995817,"domain_scores_codex":[0.9999305,0.00001061984,0.000006445217,0.0000159742,0.00001401915,0.00002233852],"domain_scores_gemma":[0.9999427,0.000006745309,0.00001835933,0.000004634693,0.00001021771,0.00001732761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001280023,0.00001059563,0.0003624887,0.00003151552,0.000004303868,0.00004870305,0.000008044741,0.00004246582,0.9983084,0.00004255562,0.00004207636,0.0009708568],"study_design_scores_gemma":[0.00002147238,0.0001967837,0.01399586,0.000007526616,0.00001465615,0.0004124631,0.00003711707,0.00171677,0.9798691,0.00007979522,0.003643814,0.000004759974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964552,0.001377022,0.001148368,0.00008333461,0.00001843968,0.00001114952,0.0001575018,0.00003654931,0.0007125463],"genre_scores_gemma":[0.9971128,0.000300537,0.001025282,0.00002481456,0.000006483841,0.000009401401,0.0002132058,0.000005278167,0.001302117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001042362,"threshold_uncertainty_score":0.003487051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.129698489176567,"score_gpt":0.3762659735579907,"score_spread":0.2465674843814238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}