{"id":"W4409987123","doi":"10.1158/0008-5472.can-24-3425","title":"Targeting Intracellular Innate RNA-Sensing Systems Overcomes Resistance to CAR T-cell Therapy in Solid Tumors","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ovarian Cancer Canada","funders":"European Research Council; Hector Stiftung; Bayerisches Staatsministerium für Wirtschaft und Medien, Energie und Technologie; Hector Stiftung II; Deutsche Krebshilfe; Technische Universität München; Elitenetzwerk Bayern; José Carreras Leukämie-Stiftung; Fritz-Bender-Stiftung; Jung-Stiftung für Wissenschaft und Forschung; Bundesministerium für Bildung und Forschung; Ludwig-Maximilians-Universität München; Deutsche Forschungsgemeinschaft; Wilhelm Sander-Stiftung; European Commission; Horizon 2020 Framework Programme; Else Kröner-Fresenius-Stiftung; Bayerische Forschungsstiftung; European Hematology Association; Melanoma Research Alliance","keywords":"Intracellular; Cancer research; RNA; Innate immune system; Solid tumor; Cancer; Medicine; Biology; Cell biology; Immunology; Internal medicine; Biochemistry; Gene; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001724964,0.0003379892,0.0005593054,0.0002620934,0.0001039471,0.0004005765,0.0002015642,0.000292128,0.0008656283],"category_scores_gemma":[0.0001287314,0.0001111821,0.0002575734,0.0001463799,0.0002205189,0.0001906413,0.0001920368,0.0007854661,0.0003330374],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002142652,"about_ca_system_score_gemma":0.0002680595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000329713,"about_ca_topic_score_gemma":0.0004352257,"domain_scores_codex":[0.9998123,0.00003486007,0.00001634108,0.00002894326,0.00004368347,0.00006387518],"domain_scores_gemma":[0.9998999,0.00002036381,0.00002264278,0.00002106705,0.0000118004,0.00002427292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001384309,0.0001410612,0.0001748071,0.0000479809,0.00001065424,0.00005420423,0.00002855798,0.0002803559,0.9934995,0.0002251679,0.00007950003,0.005319823],"study_design_scores_gemma":[0.00005382615,0.001991103,0.001254147,0.000004819226,0.00003674284,0.0003174288,0.00001979513,0.002026262,0.9914479,0.0000806715,0.002762501,0.000004897826],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994446,0.001497224,0.002465636,0.0001021954,0.00002677329,0.00006624058,0.00007865926,0.0001914428,0.001125706],"genre_scores_gemma":[0.9973437,0.0005919541,0.001025971,0.0000288637,0.000009679855,0.00003310559,0.0001580448,0.00001959904,0.0007890449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008656283,"threshold_uncertainty_score":0.002895832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03208046239701007,"score_gpt":0.3522655064169928,"score_spread":0.3201850440199828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}