{"id":"W4409988625","doi":"10.1186/s13195-025-01745-3","title":"Prognostic value of plasma biomarkers for informing clinical trial design in mild-to-moderate Alzheimer’s disease","year":2025,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"International Collaboration On Repair Discoveries; University of British Columbia","funders":"National Institute on Aging; University of California, San Diego; National Institutes of Health; Biohaven Pharmaceuticals","keywords":"Geriatric psychiatry; Neurology; Medicine; Disease; Clinical trial; Internal medicine; Value (mathematics); Alzheimer's disease; Oncology; Intensive care medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.2015195,0.001547219,0.002625435,0.001599816,0.0005487506,0.002861232,0.000934756,0.00214366,0.003243755],"category_scores_gemma":[0.3392013,0.0007308056,0.002528156,0.001927772,0.001231396,0.002862321,0.001385276,0.002110302,0.0005255535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00060621,"about_ca_system_score_gemma":0.002118817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001460198,"about_ca_topic_score_gemma":0.0002443774,"domain_scores_codex":[0.6850461,0.295951,0.01001746,0.004252493,0.003974327,0.0007585571],"domain_scores_gemma":[0.5000008,0.4170396,0.05384377,0.01728515,0.009230225,0.002600447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1748794,0.0009448076,0.425865,0.009514718,0.02810908,0.0004613214,0.0009173429,0.04100884,0.003443442,0.007760396,0.01228551,0.2948102],"study_design_scores_gemma":[0.04842058,0.0508202,0.3581254,0.007220022,0.03312545,0.001009745,0.000512326,0.342537,0.01020126,0.1114505,0.03584069,0.0007369784],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5849707,0.06436961,0.3116012,0.01411259,0.003298174,0.007072271,0.004409801,0.001355032,0.008810594],"genre_scores_gemma":[0.9434699,0.001313367,0.04928587,0.001298161,0.0005855486,0.003145358,0.0005671069,0.00004689179,0.0002878196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2015195,"threshold_uncertainty_score":0.9846686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2803736202043071,"score_gpt":0.5065971823650064,"score_spread":0.2262235621606993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}