{"id":"W4409990455","doi":"10.1021/acsmedchemlett.5c00038","title":"Enhanced Gram-Negative Membrane Disruption and In Vivo Efficacy via Lysine-Arginine Enrichment of Opis16a","year":2025,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Biotechnology and Biological Sciences Research Council; Engineering and Physical Sciences Research Council; Medical Research Council","keywords":"Lysine; In vivo; Arginine; Gram; Chemistry; Membrane; Biochemistry; Biology; Bacteria; Amino acid; Biotechnology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001325006,0.0001707534,0.0002308167,0.00004220245,0.000030814,0.00000580148,0.0001295438,0.0001041377,0.00003362407],"category_scores_gemma":[0.0000937244,0.0001597907,0.00004426042,0.0001736885,0.0001483196,0.000004442779,0.00007419998,0.0001282856,3.922713e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002838624,"about_ca_system_score_gemma":0.00004129887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004496217,"about_ca_topic_score_gemma":0.000001911685,"domain_scores_codex":[0.9990238,0.00002598824,0.0002888941,0.0003203847,0.0001466217,0.000194314],"domain_scores_gemma":[0.9995413,0.00005133171,0.0001035633,0.0002071762,0.0000419076,0.00005475329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002132121,0.00004961725,0.0004655373,0.0001536886,0.00006087782,0.000009903326,0.0001329797,0.0001495175,0.9973041,0.000003546907,0.001058118,0.0003988811],"study_design_scores_gemma":[0.001508857,0.00004070562,0.0007378931,0.0001410378,0.00004434757,0.000009750381,0.00016622,0.00004438741,0.9966586,0.00001590659,0.0004955496,0.0001367911],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942557,0.0007996264,0.002770504,0.00126578,0.00005948473,0.0001200299,0.000004570234,0.000007216589,0.0007170507],"genre_scores_gemma":[0.9984514,0.000176486,0.0001697573,0.0006646439,0.0001611098,0.00001631141,0.00005265208,0.00000924832,0.0002984356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004195618,"threshold_uncertainty_score":0.6516075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004898745436180845,"score_gpt":0.2501597785461603,"score_spread":0.2452610331099794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}