{"id":"W4409993109","doi":"10.1038/s41598-025-99031-7","title":"The differential impact of HNRNPA1 isoforms on gene expression and their relevance to dsRNA-mediated innate immune response","year":2025,"lang":"en","type":"article","venue":"Scientific Reports","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; ALS Society of Canada","keywords":"Innate immune system; Gene expression; RNA silencing; Gene isoform; Immune system; Biology; Gene; Relevance (law); Cell biology; RNA; RNA interference; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007026159,0.0001110362,0.0001073063,0.0000820491,0.0002461862,0.0000815978,0.0001085102,0.00005982233,0.00001025492],"category_scores_gemma":[0.0008259416,0.0000612973,0.00009993553,0.0001994692,0.0001620253,0.000004590257,0.0001301272,0.00004028139,0.000001699002],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001588641,"about_ca_system_score_gemma":0.0001587029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005850475,"about_ca_topic_score_gemma":0.000002498196,"domain_scores_codex":[0.9989333,0.00008439216,0.0003008041,0.0003717271,0.0001410472,0.0001687481],"domain_scores_gemma":[0.9988648,0.00004785153,0.0001550183,0.000717897,0.0001205936,0.00009379217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001086563,0.0000389321,0.00123072,0.000004454203,0.0000177105,0.000004563648,0.0000454913,0.0000837957,0.9915935,0.000005210067,0.003666595,0.00222244],"study_design_scores_gemma":[0.0002433731,0.0000936988,0.09313755,0.00003445354,0.000004387787,0.000007261996,0.00003194203,0.0000893379,0.897597,0.0004127036,0.008265337,0.00008291641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977859,0.0004418958,0.0003491924,0.0001693992,0.0009040959,0.0002135827,0.0000116271,0.000008686137,0.0001155702],"genre_scores_gemma":[0.9952238,0.00002799443,0.00002927353,0.00002791225,0.00001862229,0.00001302612,0.00006762436,0.000006595886,0.004585125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09399649,"threshold_uncertainty_score":0.2499631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005370285201241385,"score_gpt":0.25913633280418,"score_spread":0.2537660476029386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}