{"id":"W4409994213","doi":"10.1016/j.actbio.2025.04.061","title":"Invasive phenotypes of triple-negative breast cancer-associated fibroblasts are mechanosensitive, AhR-dependent and correlate with disease state","year":2025,"lang":"en","type":"article","venue":"Acta Biomaterialia","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University and Génome Québec Innovation Centre; McGill Genome Centre; McGill University; McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canadian Cancer Society; McGill University; Génome Québec; National Natural Science Foundation of China; Fondation du cancer du sein du Québec; Canadian Institutes of Health Research; Cancer Research Society; Merck","keywords":"Mechanosensitive channels; Triple-negative breast cancer; Phenotype; Breast cancer; Cancer research; Triple negative; Cancer; Materials science; Medicine; Oncology; Internal medicine; Biology; Genetics; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001347316,0.000206696,0.0001926367,0.0003285742,0.0001866654,0.0003094849,0.00008330945,0.0001868208,0.002278183],"category_scores_gemma":[0.0001950994,0.0001462772,0.0001782496,0.0001824659,0.0001717031,0.0001680505,0.0002032598,0.0003438217,0.0004756831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000114031,"about_ca_system_score_gemma":0.0001373815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005986413,"about_ca_topic_score_gemma":0.00118652,"domain_scores_codex":[0.9997732,0.00002056195,0.00002036964,0.00003312603,0.00008054974,0.00007212291],"domain_scores_gemma":[0.9997318,0.00005294608,0.0000586761,0.00004307541,0.00004044924,0.00007313802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006925075,0.0000189026,0.001132653,0.000009689714,0.000003305438,0.00007514023,0.00002492304,0.00001085575,0.9980273,0.00003425448,0.00002888467,0.0005648279],"study_design_scores_gemma":[0.00001240457,0.0004109924,0.1126023,0.000008771534,0.00002869372,0.001848751,0.0003442972,0.0005645027,0.8822272,0.0001638942,0.001769034,0.00001913568],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962611,0.000490322,0.001032161,0.00004633728,0.00001684731,0.00001338729,0.0005706893,0.00003618659,0.001533028],"genre_scores_gemma":[0.9968901,0.0002781454,0.0003782348,0.00002989683,0.00000404441,0.00002364592,0.0005849629,0.00000829802,0.001802603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002278183,"threshold_uncertainty_score":0.007621288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007669925737900921,"score_gpt":0.2427929453000825,"score_spread":0.2351230195621816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}