{"id":"W4409994539","doi":"10.1001/jamaoncol.2025.0908","title":"Modeling Population-Level Impacts of Cell-Free DNA Screening for Colorectal Cancer in Canada","year":2025,"lang":"en","type":"article","venue":"JAMA Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; Providence Health Care; BC Cancer Agency; Alberta Health Services; University of Calgary","funders":"","keywords":"Medicine; Colorectal cancer; Colonoscopy; Population; Cell-free fetal DNA; Cancer; Colorectal cancer screening; Internal medicine; Oncology; Demography; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001147684,0.0000915469,0.0001967363,0.00005442365,0.00003326799,0.000005602144,0.0001678409,0.0001437412,0.000006535167],"category_scores_gemma":[0.0002637307,0.0001013198,0.00004637791,0.00008396294,0.00001848898,0.00000232365,0.000112902,0.00006665968,5.774315e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003335346,"about_ca_system_score_gemma":0.002415789,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.7571723,"about_ca_topic_score_gemma":0.9821269,"domain_scores_codex":[0.9992529,0.00002145596,0.0002634247,0.0001968058,0.00005149695,0.000213953],"domain_scores_gemma":[0.9995407,0.00008273579,0.00007703323,0.0001559341,0.0001006014,0.00004300099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001569329,0.0001574579,0.1519525,0.0002123822,0.0001461604,0.000009272959,0.0001349103,0.2439317,0.5429489,0.0006484441,0.01523933,0.04304964],"study_design_scores_gemma":[0.0141854,0.001077379,0.2213939,0.0001977176,0.0001530158,0.000007167055,0.001065273,0.2322637,0.5070277,0.001677062,0.02014401,0.0008077081],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926163,0.0007300983,0.004490107,0.0006493875,0.0003409791,0.0002363372,0.0004261573,0.000001765591,0.0005088496],"genre_scores_gemma":[0.9965677,0.0002138648,0.002257193,0.0006149618,0.0001135207,0.00006583737,0.0001115654,0.00001072007,0.00004464747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2249546,"threshold_uncertainty_score":0.4285506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01628917385512593,"score_gpt":0.2875883100314656,"score_spread":0.2712991361763397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}