{"id":"W4410002553","doi":"10.1200/jco-25-00690","title":"Acalabrutinib Plus Bendamustine-Rituximab in Untreated Mantle Cell Lymphoma","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Juno Therapeutics; Swedish Orphan Biovitrum; Karyopharm Therapeutics; Gilead Sciences; BeiGene; Sanofi; Pharmacyclics; Genentech; Galápagos; Cilag; TG Therapeutics; Pfizer; MorphoSys; Celgene; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Bendamustine; Medicine; Mantle cell lymphoma; Rituximab; Oncology; Lymphoma; Internal medicine; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001132527,0.0004009139,0.001635179,0.0004076273,0.000246873,0.0003463449,0.0004503727,0.0004378022,0.001489743],"category_scores_gemma":[0.001639505,0.0002458048,0.0005537978,0.0004470829,0.0004304527,0.0003796919,0.0002626592,0.0006033363,0.0002857007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005577354,"about_ca_system_score_gemma":0.0004963786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007272239,"about_ca_topic_score_gemma":0.002067548,"domain_scores_codex":[0.9992645,0.0004454603,0.0000612351,0.00007976203,0.00009460718,0.00005437862],"domain_scores_gemma":[0.9995866,0.0001760624,0.00008449935,0.00002916913,0.00001534521,0.0001082972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5895672,0.009605263,0.02145603,0.001813526,0.002235209,0.0007771409,0.0002553227,0.005166111,0.02957975,0.0003935914,0.001517143,0.3376338],"study_design_scores_gemma":[0.3731255,0.5208541,0.07898948,0.0002748591,0.002885584,0.001301979,0.0001323365,0.005301012,0.00546882,0.001264098,0.01034347,0.00005880839],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853027,0.01182262,0.0005082858,0.0001969379,0.0001000803,0.0004189683,0.0001493525,0.00003234362,0.001468628],"genre_scores_gemma":[0.9963972,0.002191245,0.0004473325,0.0001616949,0.0001284903,0.0002197831,0.0001244422,0.000004125872,0.0003256769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001635179,"threshold_uncertainty_score":0.005989492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07492511335142048,"score_gpt":0.4563691692280959,"score_spread":0.3814440558766754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}