{"id":"W4410003738","doi":"10.1101/2025.04.28.651045","title":"B cells maintain the homeostasis of splenic marginal zone antigen-presenting cells to promote the anti-viral CD8 <sup>+</sup> T cell response","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Deutsche Forschungsgemeinschaft","keywords":"Cytotoxic T cell; Homeostasis; Cell biology; CD8; Antigen; Immunology; Biology; Virology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000135801,0.0004214586,0.000190829,0.0003746134,0.0001374425,0.0004128696,0.0002191723,0.0002444324,0.002159742],"category_scores_gemma":[0.00009348772,0.0001361731,0.0001609304,0.00007554824,0.0001857694,0.0001920132,0.0002887798,0.0007851745,0.001221445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002014358,"about_ca_system_score_gemma":0.0001369763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002721904,"about_ca_topic_score_gemma":0.0003123006,"domain_scores_codex":[0.9998143,0.00002660079,0.00001720073,0.00003368394,0.00004391622,0.00006441049],"domain_scores_gemma":[0.9997998,0.00001302799,0.00004299937,0.00002238138,0.00003826457,0.00008357766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006519167,0.00001612256,0.0002433363,0.00001763234,0.000001873934,0.00002647215,0.000009044999,0.00001667749,0.9987515,0.00006735062,0.00003305616,0.0007517146],"study_design_scores_gemma":[0.00003577261,0.0004350013,0.009590476,0.00001912715,0.00001712308,0.0003732465,0.00007928495,0.001062647,0.9824639,0.0001379797,0.005780847,0.000004549434],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931909,0.001638789,0.002302111,0.0001015769,0.00004046873,0.00002820483,0.0003008438,0.0002149718,0.002182059],"genre_scores_gemma":[0.9944152,0.0003066477,0.00141077,0.00006705654,0.00002915455,0.00003042151,0.0003544377,0.00004030126,0.003345953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002159742,"threshold_uncertainty_score":0.007225037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009234126171616511,"score_gpt":0.2169442676335049,"score_spread":0.2077101414618884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}