{"id":"W4410016902","doi":"10.1101/2025.04.29.647813","title":"Whey Protein Phospholipid Concentrate Supplementation Prevents High-Fat Diet Induced Cognitive Impairment in Wistar Rats by Promoting Brain Neuronal Connectivity and Sphingolipid Clearance","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Diet and metabolism studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Dairy Management","keywords":"Sphingolipid; Phospholipid; Cognitive impairment; Cognition; Endocrinology; Internal medicine; Neuroscience; Pharmacology; Chemistry; Psychology; Medicine; Biochemistry; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001860809,0.0009576739,0.0007007289,0.00098984,0.0003298542,0.0003556434,0.0003742946,0.0005402783,0.001016033],"category_scores_gemma":[0.0002252561,0.0002947559,0.0004571752,0.0002709804,0.0005284544,0.0003656484,0.0003891149,0.00110789,0.0003263916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004376776,"about_ca_system_score_gemma":0.0004985202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003137378,"about_ca_topic_score_gemma":0.004991151,"domain_scores_codex":[0.9998283,0.0000155764,0.00001623266,0.00003901435,0.00003118702,0.00006960582],"domain_scores_gemma":[0.9995474,0.00002241259,0.0001682786,0.00003593654,0.00006265969,0.0001633194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003784518,0.001131481,0.0008865257,0.0001063299,0.00003581469,0.0001078454,0.00005165516,0.00006267489,0.9902118,0.00004727981,0.00008003972,0.003494003],"study_design_scores_gemma":[0.0004076377,0.01327471,0.0316271,0.00005491502,0.000198881,0.0002232453,0.0003147767,0.0007980585,0.9513022,0.000171815,0.001591967,0.00003466738],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986227,0.0003462487,0.0004161927,0.00006838806,0.0000185096,0.00002120217,0.0002126854,0.0000731164,0.0002210889],"genre_scores_gemma":[0.9930097,0.00106382,0.001933229,0.000106386,0.00001886473,0.0001221537,0.0005480179,0.00003073637,0.003167099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003137378,"threshold_uncertainty_score":0.006238222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01233548319055376,"score_gpt":0.2521762217589772,"score_spread":0.2398407385684235,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}