{"id":"W4410019298","doi":"10.1186/s13148-025-01865-5","title":"DNA methylation in melanoma immunotherapy: mechanisms and therapeutic opportunities","year":2025,"lang":"en","type":"review","venue":"Clinical Epigenetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Yale Center for Clinical Investigation, Yale School of Medicine; Fonds de Recherche du Québec - Santé; Melanoma Research Alliance; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; Yale University; American Skin Association","keywords":"DNA methylation; Biology; Cancer research; Melanoma; Methylation; Immune system; Immunotherapy; Immunology; DNA; Genetics; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001382812,0.0004820655,0.001334529,0.0002122854,0.00007318168,0.0000540709,0.0003382326,0.001178048,0.00001959731],"category_scores_gemma":[0.0002977885,0.0004415307,0.0004469173,0.0001896989,0.0001694611,0.000002261375,0.0002167268,0.0003767764,0.000005717284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000258431,"about_ca_system_score_gemma":0.0005006813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007255861,"about_ca_topic_score_gemma":0.00003061013,"domain_scores_codex":[0.9963812,0.0008592875,0.001497598,0.0007585514,0.000173233,0.000330118],"domain_scores_gemma":[0.9981582,0.0004567984,0.0004656244,0.0007083305,0.0000902297,0.0001208713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001463299,0.00007613607,0.00006634266,0.001160239,0.0001535354,0.000003630468,0.000009675054,0.000005765473,0.0001439296,0.0006119349,0.00001471551,0.9977394],"study_design_scores_gemma":[0.0004985454,0.0005203963,0.000254025,0.00134816,0.0003262629,0.000002091337,0.00001918317,0.00002882813,0.000390322,0.005672464,0.9903707,0.0005690552],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005473589,0.9918975,0.005496279,0.00003750129,0.0005358647,0.0007168314,0.00005087031,0.00001441679,0.0007033491],"genre_scores_gemma":[0.0004882445,0.9961571,0.001474804,0.0001603072,0.0002195417,0.00008646662,0.0003172988,0.00007117121,0.001025061],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9971704,"threshold_uncertainty_score":0.9998037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1186925017478074,"score_gpt":0.4064858092958948,"score_spread":0.2877933075480875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}