{"id":"W4410020778","doi":"10.1038/s41467-025-59459-x","title":"Biomimetic culture substrates for modelling homeostatic intestinal epithelium in vitro","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"3D Printing in Biomedical Research","field":"Engineering","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"In vitro; Intestinal epithelium; Homeostasis; Cell biology; Epithelium; Biology; Intestinal mucosa; Computational biology; Biochemistry; Medicine; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003740499,0.0001129319,0.0001452486,0.0002830922,0.0001080708,0.00004712651,0.001022098,0.0002289532,0.000004166548],"category_scores_gemma":[0.0005821435,0.0001080312,0.00005024367,0.0008188291,0.0001250988,0.00005512619,0.0001524142,0.001171498,0.000009528017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001056477,"about_ca_system_score_gemma":0.00005763644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001311203,"about_ca_topic_score_gemma":0.00004640839,"domain_scores_codex":[0.9991994,0.00005195136,0.0002427053,0.0001327044,0.0001161868,0.0002570553],"domain_scores_gemma":[0.9979633,0.001038014,0.00001916016,0.0007987116,0.0001299445,0.00005088913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002826355,0.001237346,0.004783725,0.002722475,0.0006292243,0.00001085323,0.004230336,0.08189498,0.5357207,0.2004354,0.03237321,0.1356791],"study_design_scores_gemma":[0.0004024277,0.00001291062,0.000577844,0.0002073481,0.00001450607,0.000001715783,0.000141565,0.9414333,0.02157294,0.01228762,0.02318028,0.0001675161],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1525658,0.1584122,0.6194074,0.02536842,0.001580421,0.004174692,0.0002884443,0.002024505,0.03617812],"genre_scores_gemma":[0.8933676,0.0007620589,0.1054213,0.00007445344,0.00001429882,0.0001423254,0.00008895524,0.00001613308,0.0001128436],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.8595384,"threshold_uncertainty_score":0.5089639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02829424190340772,"score_gpt":0.3333025810821572,"score_spread":0.3050083391787495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}