{"id":"W4410020778","doi":"10.1038/s41467-025-59459-x","title":"Biomimetic culture substrates for modelling homeostatic intestinal epithelium in vitro","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"3D Printing in Biomedical Research","field":"Engineering","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"In vitro; Intestinal epithelium; Homeostasis; Cell biology; Epithelium; Biology; Intestinal mucosa; Computational biology; Biochemistry; Medicine; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003634998,0.00045176,0.0001998713,0.0003899309,0.0001891903,0.0005883031,0.0003249928,0.0006050195,0.001099009],"category_scores_gemma":[0.0003035438,0.0002609235,0.0003167433,0.0002836953,0.0001922286,0.0002689837,0.0003169357,0.0005193658,0.0006287493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002019047,"about_ca_system_score_gemma":0.0002582313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000548541,"about_ca_topic_score_gemma":0.001413822,"domain_scores_codex":[0.9998086,0.00002655856,0.0000281746,0.00003681044,0.00007973357,0.00002021174],"domain_scores_gemma":[0.9997442,0.00007679359,0.00005474698,0.00007322142,0.00003530338,0.00001576963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001924775,0.00001950955,0.000268925,0.00014078,0.000004687018,0.0001358104,0.00005449446,0.001886885,0.9936894,0.000371777,0.0000588934,0.003349581],"study_design_scores_gemma":[0.000005558056,0.0001486916,0.001787298,0.00003673075,0.00001935654,0.0004045405,0.0000610537,0.008788297,0.9786773,0.0001927196,0.009866682,0.00001167965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7176606,0.006327455,0.255271,0.000257628,0.0003166314,0.0004253985,0.002562953,0.0008598077,0.01631855],"genre_scores_gemma":[0.8287644,0.003155848,0.1620599,0.00009138386,0.0000236241,0.0005154814,0.001395885,0.0001113488,0.003882133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001099009,"threshold_uncertainty_score":0.003676593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02829424190340772,"score_gpt":0.3333025810821572,"score_spread":0.3050083391787495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}