{"id":"W4410028751","doi":"10.3390/biom15050636","title":"Microbial Composition, Disease Trajectory and Genetic Background in a Slow Onset Model of Frontotemporal Lobar Degeneration","year":2025,"lang":"en","type":"article","venue":"Biomolecules","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Prion Research Institute; Canadian Institutes of Health Research; Directorate for Biological Sciences; Canada Foundation for Innovation; University of Alberta; Campus Alberta Neuroscience","keywords":"Congenic; Biology; Genetically modified mouse; Inbred strain; Transplantation; Neuropathology; Transgene; Genetics; Gene; Internal medicine; Disease; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003188494,0.0001030475,0.0001578565,0.0001477251,0.00003771414,0.00001410621,0.00003495937,0.00004025915,0.000008490852],"category_scores_gemma":[0.000006912591,0.00009511581,0.00005004947,0.0001079667,0.0001409372,0.00003841699,0.00002405618,0.00003854577,0.000003205337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006261099,"about_ca_system_score_gemma":0.0003387035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001378072,"about_ca_topic_score_gemma":0.00008018846,"domain_scores_codex":[0.9993042,0.00005307358,0.0001736053,0.0001989486,0.0001255052,0.0001446682],"domain_scores_gemma":[0.9996112,0.00001181922,0.00002723433,0.0001427148,0.00005271988,0.0001542955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00604206,0.004035198,0.5331309,0.0008733451,0.002843466,0.0008533766,0.000228021,0.0004281112,0.4428954,0.001066259,0.004669784,0.002934052],"study_design_scores_gemma":[0.007947816,0.0002904182,0.9171921,0.0004549748,0.0007155443,0.00001729952,0.00007993874,0.03127024,0.0408504,0.0008927084,0.00002551015,0.0002630752],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884197,0.009004147,0.001574198,0.0003899536,0.00001775243,0.0003471017,0.0001579428,0.00001203784,0.00007722293],"genre_scores_gemma":[0.9969834,0.0001196511,0.002488215,0.0001275855,0.00001146374,0.00002230855,0.0002088672,0.000007982276,0.00003048847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.402045,"threshold_uncertainty_score":0.387871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02400169578490334,"score_gpt":0.2988517940406329,"score_spread":0.2748500982557296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}