{"id":"W4410028751","doi":"10.3390/biom15050636","title":"Microbial Composition, Disease Trajectory and Genetic Background in a Slow Onset Model of Frontotemporal Lobar Degeneration","year":2025,"lang":"en","type":"article","venue":"Biomolecules","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Prion Research Institute; Canadian Institutes of Health Research; Directorate for Biological Sciences; Canada Foundation for Innovation; University of Alberta; Campus Alberta Neuroscience","keywords":"Congenic; Biology; Genetically modified mouse; Inbred strain; Transplantation; Neuropathology; Transgene; Genetics; Gene; Internal medicine; Disease; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001887521,0.0004561161,0.0003442447,0.0009568935,0.0003268182,0.0004168921,0.0001789621,0.0003850196,0.001113187],"category_scores_gemma":[0.0001574068,0.00018201,0.0001712357,0.0002487188,0.0002805628,0.0002928679,0.0002289011,0.000703798,0.0003077428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004584999,"about_ca_system_score_gemma":0.0003247456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001588832,"about_ca_topic_score_gemma":0.003558231,"domain_scores_codex":[0.9997831,0.00002646007,0.00001787289,0.00005448783,0.00004869161,0.00006929105],"domain_scores_gemma":[0.999693,0.00001327331,0.00007791573,0.00002003887,0.00002533703,0.0001703513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003261759,0.000802726,0.003442415,0.00002340585,0.00001313867,0.00015423,0.00007028431,0.00007309653,0.9900776,0.00007002365,0.00008572271,0.001925606],"study_design_scores_gemma":[0.0005255416,0.02036714,0.3272139,0.00006817286,0.0002878331,0.002043468,0.0006613647,0.004073988,0.6408123,0.000573783,0.003278284,0.00009425393],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991173,0.0001321633,0.0001673995,0.00003261949,0.000008973567,0.00001429084,0.0002381196,0.00001700184,0.0002721461],"genre_scores_gemma":[0.9959609,0.0002508745,0.0005991182,0.00006043538,0.000009040654,0.00008328979,0.0005615872,0.00002126631,0.002453521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001588832,"threshold_uncertainty_score":0.003723919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02400169578490334,"score_gpt":0.2988517940406329,"score_spread":0.2748500982557296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}