{"id":"W4410028983","doi":"10.3390/cells14090653","title":"Targeted Redox Regulation α-Ketoglutarate Dehydrogenase Complex for the Treatment of Human Diseases","year":2025,"lang":"en","type":"review","venue":"Cells","topic":"Biochemical Acid Research Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Oxidative phosphorylation; Citric acid cycle; Mitochondrion; Pyruvate dehydrogenase complex; Biochemistry; Dihydrolipoamide dehydrogenase; Oxidative stress; Biology; Cell biology; Chemistry; Metabolism; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006186451,0.000284041,0.0006797198,0.00004349594,0.0001467596,0.00001325737,0.0002641082,0.0001886626,0.00002122611],"category_scores_gemma":[0.00005747116,0.0001501134,0.0006233988,0.0001174058,0.000210678,7.936605e-7,0.0001012139,0.00004463684,0.000003477089],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000431672,"about_ca_system_score_gemma":0.0001319317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006833402,"about_ca_topic_score_gemma":0.000003740703,"domain_scores_codex":[0.99885,0.00008795937,0.0003435739,0.0003794997,0.0001078531,0.0002311022],"domain_scores_gemma":[0.9989839,0.0001422233,0.0001825855,0.0005235912,0.0001100808,0.00005765926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001314479,0.000744805,0.000003102228,0.02198875,0.002564336,0.000002444889,0.00002849216,0.00001150398,0.3514958,0.00005123578,0.03928049,0.5836976],"study_design_scores_gemma":[0.0002354332,0.0003646018,0.00000322558,0.0004335331,0.0006211796,3.684827e-7,0.000004142493,0.000007660848,0.1384787,0.0000327686,0.8596745,0.0001439522],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001089166,0.9970304,0.00007998652,0.00002792221,0.00007238624,0.001559238,0.001031034,0.000007816256,0.0000823451],"genre_scores_gemma":[0.0004008406,0.9933238,0.0001082856,0.0000116077,0.0002155589,0.0004905106,0.002659416,0.00002301773,0.00276698],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.820394,"threshold_uncertainty_score":0.6121446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04760586948029007,"score_gpt":0.3659489149870677,"score_spread":0.3183430455067776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}