{"id":"W4410028983","doi":"10.3390/cells14090653","title":"Targeted Redox Regulation α-Ketoglutarate Dehydrogenase Complex for the Treatment of Human Diseases","year":2025,"lang":"en","type":"review","venue":"Cells","topic":"Biochemical Acid Research Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Oxidative phosphorylation; Citric acid cycle; Mitochondrion; Pyruvate dehydrogenase complex; Biochemistry; Dihydrolipoamide dehydrogenase; Oxidative stress; Biology; Cell biology; Chemistry; Metabolism; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003127354,0.0003503254,0.0005881882,0.0004682307,0.0001524491,0.0004966024,0.0004386927,0.0005441495,0.00310984],"category_scores_gemma":[0.0002588237,0.00007527921,0.0004544142,0.0003366064,0.0001869896,0.0002703624,0.0005076806,0.001129768,0.00105482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003726881,"about_ca_system_score_gemma":0.0002970013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003859635,"about_ca_topic_score_gemma":0.0005203213,"domain_scores_codex":[0.999855,0.00003120925,0.00001285112,0.00002908317,0.0000452941,0.00002650039],"domain_scores_gemma":[0.9999276,0.000008551165,0.0000173178,0.000006081497,0.00002443986,0.00001603753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002057074,0.0007961836,0.001236901,0.005603692,0.0004540638,0.0009467348,0.0001463724,0.0008875905,0.2234864,0.01134634,0.04340707,0.7096315],"study_design_scores_gemma":[0.0007254834,0.001962436,0.004996964,0.001125248,0.0005077988,0.002956936,0.0001225346,0.002126867,0.0899333,0.006558864,0.8889225,0.00006114177],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04090791,0.9184279,0.02159277,0.004161211,0.002126236,0.0002198144,0.0006543492,0.0006074901,0.01130231],"genre_scores_gemma":[0.4119288,0.5439286,0.01830206,0.003279125,0.001474915,0.0004803777,0.002400842,0.0001328443,0.0180724],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00310984,"threshold_uncertainty_score":0.01040345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04760586948029007,"score_gpt":0.3659489149870677,"score_spread":0.3183430455067776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}