{"id":"W4410030770","doi":"10.1016/j.jconrel.2025.113812","title":"Radiation-guided nanoparticles enhance the efficacy of PARP inhibitors in primary and metastatic BRCA1-deficient tumors via immunotherapy","year":2025,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"H2020 European Research Council; Fundação para a Ciência e a Tecnologia; National Cancer Institute; European Research Council; Israel Cancer Research Fund; Israel Science Foundation; Egg Farmers of Canada; Tel Aviv University; Teva Pharmaceutical Industries","keywords":"Immunotherapy; Primary (astronomy); Medicine; Cancer research; Nanoparticle; Internal medicine; Nanotechnology; Cancer; Materials science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001096257,0.0002858647,0.0002899297,0.000122338,0.00009782337,0.0002398398,0.0001960934,0.0003835917,0.001475763],"category_scores_gemma":[0.0001168332,0.0001360407,0.000292492,0.0000827384,0.000184758,0.0002426179,0.0001343693,0.0006316768,0.0003359493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002702897,"about_ca_system_score_gemma":0.0001737717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004913252,"about_ca_topic_score_gemma":0.0006049518,"domain_scores_codex":[0.999911,0.00001026798,0.000003263797,0.00002604197,0.00002291827,0.00002664008],"domain_scores_gemma":[0.9999589,0.00001089285,0.00001135591,0.000004367952,0.000005734298,0.000008841414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005362706,0.0001657884,0.0001025612,0.0001235556,0.00002170338,0.00005916945,0.00004178428,0.001012888,0.9882312,0.0002535274,0.0006474105,0.008804149],"study_design_scores_gemma":[0.00008026577,0.001061558,0.0008631672,0.000008130703,0.00004625793,0.0001815318,0.00001731849,0.002879228,0.9914073,0.00006509363,0.003381873,0.000008355913],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840853,0.004307438,0.006891785,0.0002270681,0.0001548459,0.00007514006,0.0002201493,0.0002711744,0.003767162],"genre_scores_gemma":[0.9939449,0.0009788127,0.001762618,0.00008946991,0.0000173664,0.00004535585,0.0001145168,0.00003132449,0.003015588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001475763,"threshold_uncertainty_score":0.004936874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008606387272397204,"score_gpt":0.2950125257560063,"score_spread":0.2864061384836091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}