{"id":"W4410031582","doi":"10.1016/j.jval.2025.04.2159","title":"Cost-Utility Analysis of Durvalumab and Tremelimumab Versus Best Supportive Care in Refractory Metastatic Colorectal Cancer","year":2025,"lang":"en","type":"article","venue":"Value in Health","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; Queen's University; Sunnybrook Health Science Centre; Kingston Health Sciences Centre","funders":"","keywords":"Durvalumab; Tremelimumab; Refractory (planetary science); Colorectal cancer; Medicine; Oncology; Internal medicine; Cancer; Immunotherapy; Nivolumab; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003940341,0.001131307,0.002738664,0.001209549,0.0001934172,0.001731902,0.001064099,0.0008409038,0.003340339],"category_scores_gemma":[0.01302931,0.0004370919,0.004502445,0.001228842,0.0005845953,0.001081605,0.000772839,0.001455956,0.0001656899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00490477,"about_ca_system_score_gemma":0.001722259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01020311,"about_ca_topic_score_gemma":0.005274637,"domain_scores_codex":[0.9973752,0.001951968,0.00009328894,0.0001524784,0.000194559,0.0002324883],"domain_scores_gemma":[0.9934052,0.005263376,0.0005813186,0.0001326429,0.0001735918,0.0004437872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.3428893,0.002253687,0.06919079,0.002351654,0.02038104,0.0008236036,0.0001885474,0.4402553,0.003121699,0.007314116,0.003935793,0.1072946],"study_design_scores_gemma":[0.02273653,0.04249052,0.1356256,0.0007500172,0.02633636,0.001213073,0.0007779542,0.7562059,0.002202602,0.007248278,0.004180489,0.0002327526],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824683,0.009820602,0.002189483,0.001035484,0.00008320734,0.0002676831,0.001751505,0.00004478642,0.002339081],"genre_scores_gemma":[0.9980779,0.0006507356,0.0004815552,0.00008831615,0.0000204209,0.00004140799,0.0003979599,0.000006084795,0.0002356056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01020311,"threshold_uncertainty_score":0.03558683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06745000253906976,"score_gpt":0.3929510278730196,"score_spread":0.3255010253339499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}