{"id":"W4410032464","doi":"10.1016/j.cell.2025.03.048","title":"Long-term histone lactylation connects metabolic and epigenetic rewiring in innate immune memory","year":2025,"lang":"en","type":"article","venue":"Cell","topic":"Immune responses and vaccinations","field":"Immunology and Microbiology","cited_by":107,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"European Research Council; Deutsche Forschungsgemeinschaft; Horizon 2020 Framework Programme; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Chan Zuckerberg Initiative; National Health and Medical Research Council; Bill and Melinda Gates Foundation","keywords":"Biology; Epigenetics; Innate immune system; Histone; Epigenesis; Immunological memory; Term (time); Immune system; Computational biology; Genetics; Cell biology; DNA methylation; Immunity; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002115649,0.0001024263,0.0001988126,0.0002557392,0.0001134065,0.00001105823,0.00008915902,0.0001276952,0.0001519708],"category_scores_gemma":[0.00005310997,0.0001036311,0.00003542842,0.0001874721,0.00004887094,0.00005451859,0.00007713539,0.0001710299,0.00007383738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003256512,"about_ca_system_score_gemma":0.00004807568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009017494,"about_ca_topic_score_gemma":0.00005146799,"domain_scores_codex":[0.9992295,0.0001570016,0.0002294594,0.0001764097,0.0000119596,0.000195665],"domain_scores_gemma":[0.999581,0.0001314047,0.00006131791,0.0001875112,0.0000309874,0.000007759365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001186947,0.0000982297,0.008223347,0.00005913636,0.00004347343,0.000005942064,0.0004987722,0.00001547417,0.9750957,0.0006475593,0.0001032844,0.01509033],"study_design_scores_gemma":[0.001377084,0.00002113726,0.5992342,0.00003672171,0.0000307132,0.000006085918,0.00005490565,0.000009076787,0.3964085,0.0000854873,0.002642627,0.00009348166],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9115227,0.08494363,0.0001269808,0.0002348877,0.0003994641,0.000173365,0.000002131701,0.00002591351,0.002570856],"genre_scores_gemma":[0.9810394,0.001159646,0.00001659632,0.00006304787,0.00000551415,0.00001520738,0.00003163142,0.000007823668,0.01766111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5910108,"threshold_uncertainty_score":0.4225952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008950700097512044,"score_gpt":0.2602196667114815,"score_spread":0.2512689666139695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}