{"id":"W4410032464","doi":"10.1016/j.cell.2025.03.048","title":"Long-term histone lactylation connects metabolic and epigenetic rewiring in innate immune memory","year":2025,"lang":"en","type":"article","venue":"Cell","topic":"Immune responses and vaccinations","field":"Immunology and Microbiology","cited_by":107,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"European Research Council; Deutsche Forschungsgemeinschaft; Horizon 2020 Framework Programme; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Chan Zuckerberg Initiative; National Health and Medical Research Council; Bill and Melinda Gates Foundation","keywords":"Biology; Epigenetics; Innate immune system; Histone; Epigenesis; Immunological memory; Term (time); Immune system; Computational biology; Genetics; Cell biology; DNA methylation; Immunity; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002433586,0.0002654362,0.0002317183,0.0001601058,0.0001979634,0.0007428263,0.0004037834,0.0004499513,0.003338197],"category_scores_gemma":[0.000223528,0.0001694298,0.0002907144,0.0001419451,0.0004462592,0.0008804519,0.0006402993,0.0007207803,0.0005526087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004081503,"about_ca_system_score_gemma":0.0002049819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003498469,"about_ca_topic_score_gemma":0.001013936,"domain_scores_codex":[0.9998468,0.00001733378,0.000007367356,0.00004181513,0.00002177767,0.00006486208],"domain_scores_gemma":[0.9998301,0.00001811782,0.00005138816,0.00003078305,0.00002124149,0.0000483087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004408402,0.0000410572,0.002130825,0.00005951945,0.00002411157,0.0000991542,0.00003711703,0.0001428047,0.9867012,0.001297229,0.0001153111,0.008910833],"study_design_scores_gemma":[0.00004536308,0.00093949,0.06445496,0.00003954201,0.0000592297,0.0004889662,0.0003486538,0.00221011,0.9191805,0.003425771,0.008777419,0.00002987194],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9775785,0.008326665,0.007893459,0.0008763369,0.0001412818,0.00002020006,0.0003312577,0.0001704995,0.004661924],"genre_scores_gemma":[0.9963246,0.0007603739,0.0007149577,0.000104641,0.00002340005,0.000005117633,0.0001500987,0.00001271849,0.001904098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003338197,"threshold_uncertainty_score":0.01116735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008950700097512044,"score_gpt":0.2602196667114815,"score_spread":0.2512689666139695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}