{"id":"W4410035545","doi":"10.1002/smll.202409012","title":"Liposome‐Polymer Nanoparticles Loaded with Copper Diethyldithiocarbamate and 6‐Bromo‐Indirubin‐3′‐Oxime Enable the Treatment of Refractive Melanoma","year":2025,"lang":"en","type":"article","venue":"Small","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; McGill University Health Centre","funders":"McGill University Health Centre; McGill University","keywords":"Indirubin; Cancer research; Cytotoxicity; Tumor microenvironment; Cancer cell; Chemistry; Photothermal therapy; Pharmacology; Melanoma; Cancer; Medicine; Materials science; Biochemistry; Nanotechnology; Tumor cells; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000823904,0.0002867775,0.0001570339,0.0001608836,0.00008349388,0.0001631108,0.0001317811,0.0002730724,0.0006751669],"category_scores_gemma":[0.00005248149,0.000128777,0.000177707,0.00007785306,0.0001371629,0.0002033036,0.0001525479,0.0002902093,0.0001739474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002512404,"about_ca_system_score_gemma":0.0001520135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006944021,"about_ca_topic_score_gemma":0.0008224123,"domain_scores_codex":[0.999962,0.000004490369,0.000002358629,0.00001075143,0.000009046036,0.00001131964],"domain_scores_gemma":[0.9999779,0.000003038523,0.000007982647,0.000001883185,0.000003019585,0.0000061224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008916928,0.00001855204,0.00004535359,0.00003471046,0.000003503716,0.00003065958,0.000007749109,0.00009203352,0.9970359,0.0001178034,0.00005143035,0.002473324],"study_design_scores_gemma":[0.00001441593,0.0002100932,0.000377551,0.000002821374,0.00001124296,0.00005935125,0.000004449765,0.0009789311,0.9969427,0.00001725666,0.001378073,0.000003040136],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862466,0.002689115,0.007293006,0.0001450937,0.00006171913,0.00007719875,0.0001264841,0.0002137914,0.003146952],"genre_scores_gemma":[0.992714,0.0008797024,0.003722968,0.00004282969,0.000008170464,0.00003873316,0.00007401846,0.00001989385,0.002499764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006944021,"threshold_uncertainty_score":0.002258658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006429873218528167,"score_gpt":0.2213888652845007,"score_spread":0.2149589920659726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}