{"id":"W4410050820","doi":"10.1093/neuonc/noaf118","title":"Response Assessment in Neuro-Oncology (RANO) 2009–2025: Broad scope and implementation—A progress report","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"University of Colorado School of Medicine, Anschutz Medical Campus; National Cancer Institute; Faculty of Medicine and Health, University of Sydney; Faculty of Medicine and Health, University of Leeds; Advanced Accelerator Applications; University of California, San Francisco; Leids Universitair Medisch Centrum; University of Texas MD Anderson Cancer Center; National Institutes of Health; Eli Lilly and Company; Parker Institute for Cancer Immunotherapy; Aptitude Health; EMD Serono; Deutschen Konsortium für Translationale Krebsforschung; LEO Pharma; Universität zu Köln; Massachusetts General Hospital; Universitätsklinikum Köln; Alexion Pharmaceuticals; Cure Brain Cancer Foundation; Children's Hospital Colorado; Moffitt Cancer Center; Universiteit Leiden; Seagen; Agios Pharmaceuticals; Les Laboratories Pierre Fabre; AstraZeneca; Novocure; Department of Radiology and Biomedical Imaging, University of California, San Francisco; Amgen; Elekta; Universitätsspital Zürich; Erasmus Universiteit Rotterdam; Memorial Sloan-Kettering Cancer Center; University of Toronto; School of Medicine, Indiana University; Children's Healthcare of Atlanta; National Institute of Neurological Disorders and Stroke; Break Through Cancer; Aflac; U.S. Department of Defense; Bristol-Myers Squibb; University of Leeds; Dana-Farber Cancer Institute; Florida International University; Servier; Incyte; Pfizer; Università degli Studi di Torino; Virginia Commonwealth University; Gilead Sciences; Emory University; Brigham and Women's Hospital","keywords":"Scope (computer science); Variety (cybernetics); Medical physics; Clinical trial; Medicine; Engineering; Psychology; Computer science; Artificial intelligence; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.3324747,0.001816612,0.003052655,0.003821734,0.001352146,0.009035889,0.006266775,0.005937199,0.007352693],"category_scores_gemma":[0.1208219,0.001109182,0.004191176,0.004384166,0.001953119,0.005630791,0.01003521,0.005926255,0.004938102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01085216,"about_ca_system_score_gemma":0.08162481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.014501,"about_ca_topic_score_gemma":0.006937432,"domain_scores_codex":[0.9196932,0.04041184,0.01269106,0.003456231,0.01806912,0.005678585],"domain_scores_gemma":[0.8417532,0.04749027,0.01879949,0.005753169,0.05856877,0.02763513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004141765,0.001809347,0.01381977,0.01470331,0.0006811926,0.0002280972,0.0009527263,0.003826889,0.001717321,0.01542825,0.2007443,0.7419469],"study_design_scores_gemma":[0.002159998,0.005518164,0.0668005,0.03567497,0.0008335279,0.0004169554,0.00126148,0.005512177,0.004339534,0.005554069,0.8716655,0.0002630751],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.04933793,0.2762852,0.1492568,0.2800785,0.02201111,0.06240502,0.04596613,0.005448544,0.1092107],"genre_scores_gemma":[0.1517527,0.1241048,0.4495988,0.07723267,0.004895377,0.06786692,0.1038446,0.002551588,0.01815246],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.3324747,"threshold_uncertainty_score":0.8231776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02335022891608617,"score_gpt":0.40557643795816,"score_spread":0.3822262090420738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}