{"id":"W4410056342","doi":"10.1038/s41467-025-58523-w","title":"Liposomal lipid nanoparticles for extrahepatic delivery of mRNA","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"FPInnovations; University of British Columbia Hospital; Canada's Michael Smith Genome Sciences Centre; Spinal Cord Injury BC; University of British Columbia","funders":"British Columbia Knowledge Development Fund; Canadian Institutes of Health Research; Government of Canada","keywords":"Liposome; Nanoparticle; Computational biology; Nanotechnology; Materials science; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001709347,0.000293863,0.0001673198,0.0001540117,0.000140316,0.0002148234,0.0001336055,0.0003082049,0.0007122607],"category_scores_gemma":[0.0001469584,0.0001181266,0.0001569728,0.00007624362,0.0001571261,0.0002607897,0.0002629927,0.0004047639,0.0004650565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003445462,"about_ca_system_score_gemma":0.000187296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002445478,"about_ca_topic_score_gemma":0.0003929836,"domain_scores_codex":[0.9998958,0.00002349959,0.000008720109,0.00002126496,0.00003714388,0.00001354366],"domain_scores_gemma":[0.9999516,0.00001151566,0.0000131998,0.000005125234,0.00001110291,0.000007406793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002368751,0.000009172079,0.00003751887,0.0000462151,0.000002874753,0.00003110972,0.000009380764,0.00008678738,0.9968727,0.000201709,0.00004669762,0.00263216],"study_design_scores_gemma":[0.000007031188,0.00009600038,0.0001217433,0.000004574942,0.000007477505,0.00008706442,0.000005219234,0.0008366854,0.9961218,0.00005233786,0.002656769,0.000003190137],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8438373,0.01139434,0.135108,0.0006823244,0.0002031667,0.0002848518,0.0002779074,0.0005123505,0.007699791],"genre_scores_gemma":[0.9359615,0.003890654,0.05280665,0.0002330602,0.00002720101,0.0001700588,0.0002976613,0.00008288014,0.00653041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007122607,"threshold_uncertainty_score":0.002499878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01479592663289478,"score_gpt":0.2998657476860835,"score_spread":0.2850698210531887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}