{"id":"W4410074912","doi":"10.1007/s40120-025-00756-4","title":"Characterizing the Journey of Early Alzheimer’s Disease in Patients Initiating Lecanemab Treatment in the United States: A Real-World Evidence Study","year":2025,"lang":"en","type":"article","venue":"Neurology and Therapy","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Group for Research in Decision Analysis","funders":"Biogen","keywords":"Medicine; Neurology; Disease; Alzheimer's disease; Neuroscience; Gerontology; Internal medicine; Psychiatry; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004750517,0.0001011749,0.0001742756,0.000280792,0.00008021273,0.00001720636,0.00009691094,0.00002098089,0.00001541186],"category_scores_gemma":[0.00005504446,0.0000537045,0.00002757412,0.0004983919,0.00009137439,0.00005430385,0.00002743347,0.0002189815,6.442522e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001018887,"about_ca_system_score_gemma":0.00008046863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001560657,"about_ca_topic_score_gemma":0.0002847663,"domain_scores_codex":[0.9984481,0.000799467,0.0002299177,0.0001757182,0.0001579363,0.000188869],"domain_scores_gemma":[0.9991124,0.0005620047,0.00006229864,0.0001722084,0.00005793036,0.00003313689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003737323,0.001294708,0.9815034,0.000007664227,0.00008089428,0.00005760353,0.004341905,0.000001214856,0.00003843999,0.00002407321,0.000004532989,0.008908205],"study_design_scores_gemma":[0.003918698,0.004377461,0.9907958,0.00006535348,0.00005857067,5.406127e-7,0.0003884507,0.0000736154,0.00005487481,0.00008864811,0.0001444664,0.00003355554],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935081,0.0003849845,5.371511e-7,0.004558879,0.00003023157,0.001345723,0.000002721041,0.00000551536,0.0001632996],"genre_scores_gemma":[0.9939612,0.001957273,6.013353e-7,0.00388727,0.00001073225,0.000145393,0.00001062518,0.000005185359,0.00002171664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00929233,"threshold_uncertainty_score":0.2359258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07351256682237726,"score_gpt":0.381859147961616,"score_spread":0.3083465811392387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}