{"id":"W4410076571","doi":"10.1002/ddr.70099","title":"Novel Oxadiazole‐Based Bioisostere of Caffeic Acid Phenethyl Ester: Synthesis, Anticancer Activity, and Inhibition of Lipoxygenase Product Biosynthesis","year":2025,"lang":"en","type":"article","venue":"Drug Development Research","topic":"Insect and Pesticide Research","field":"Agricultural and Biological Sciences","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Atlantic Cancer Research Institute; Université de Moncton","funders":"Natural Sciences and Engineering Research Council of Canada; New Brunswick Innovation Foundation; Université de Moncton","keywords":"Caffeic acid phenethyl ester; Bioisostere; Caffeic acid; Biosynthesis; Chemistry; Biochemistry; Oxadiazole; Antioxidant; Enzyme; Chemical synthesis; In vitro; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002007339,0.0001640084,0.0003086453,0.0002156522,0.0002625249,0.00005696066,0.0002731608,0.00008899046,0.0002369373],"category_scores_gemma":[0.0004988134,0.0000772498,0.00005457336,0.001195322,0.0003536975,0.0001039435,0.0002694635,0.0002373292,0.000008156084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000769135,"about_ca_system_score_gemma":0.0003147062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001004815,"about_ca_topic_score_gemma":0.001190472,"domain_scores_codex":[0.9977061,0.0002941862,0.0003224919,0.0004299803,0.0007495906,0.0004976087],"domain_scores_gemma":[0.997973,0.001287083,0.00008187941,0.0001282779,0.0004224193,0.0001073431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001418549,0.0002491233,0.00706571,0.0002858364,0.0000279073,0.000002046386,0.0001237666,9.823864e-7,0.8336173,0.00005900047,0.0001552968,0.1582711],"study_design_scores_gemma":[0.000134584,0.00004366302,0.1696802,0.0003243166,0.000006512256,6.532966e-7,0.0001166994,0.0000566435,0.8286965,0.00005123975,0.0007739856,0.0001148938],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995723,0.0004519542,0.00001623632,0.002424336,0.00003535871,0.0004986612,0.00005043577,0.00001805748,0.0007819305],"genre_scores_gemma":[0.9989335,0.0001538897,0.0005529916,0.00002285517,0.00004253806,0.0000821921,0.00001796401,0.000002092632,0.0001919917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1626145,"threshold_uncertainty_score":0.3150156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05397694949200889,"score_gpt":0.3147761662077136,"score_spread":0.2607992167157048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}