{"id":"W4410076571","doi":"10.1002/ddr.70099","title":"Novel Oxadiazole‐Based Bioisostere of Caffeic Acid Phenethyl Ester: Synthesis, Anticancer Activity, and Inhibition of Lipoxygenase Product Biosynthesis","year":2025,"lang":"en","type":"article","venue":"Drug Development Research","topic":"Insect and Pesticide Research","field":"Agricultural and Biological Sciences","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Atlantic Cancer Research Institute; Université de Moncton","funders":"Natural Sciences and Engineering Research Council of Canada; New Brunswick Innovation Foundation; Université de Moncton","keywords":"Caffeic acid phenethyl ester; Bioisostere; Caffeic acid; Biosynthesis; Chemistry; Biochemistry; Oxadiazole; Antioxidant; Enzyme; Chemical synthesis; In vitro; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001407557,0.0004414973,0.0002473633,0.0003102551,0.000128158,0.0001340399,0.0003075539,0.0002510077,0.001116298],"category_scores_gemma":[0.0001105781,0.0001112811,0.0002617532,0.0002567848,0.0002123538,0.0002154532,0.0001684793,0.0003633274,0.000279949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002739154,"about_ca_system_score_gemma":0.0002214077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008781717,"about_ca_topic_score_gemma":0.001546904,"domain_scores_codex":[0.9999468,0.000007354404,0.000004437974,0.0000110243,0.00001049344,0.00001989215],"domain_scores_gemma":[0.9999559,0.000004226073,0.00001147316,0.000004481178,0.000006984648,0.00001691663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001370726,0.0001323331,0.0001939902,0.0004518393,0.00002266181,0.0004380241,0.0000714645,0.0005524774,0.9899692,0.0005586834,0.0001817651,0.00729054],"study_design_scores_gemma":[0.0001279353,0.001704203,0.002433306,0.00002628898,0.00005143139,0.0004346692,0.00003931107,0.0007157897,0.9771533,0.0001156557,0.01717678,0.00002133241],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9431968,0.03559905,0.01186867,0.0004460186,0.0001886006,0.0003504331,0.001101041,0.00009750589,0.007151814],"genre_scores_gemma":[0.9851601,0.007218986,0.004338335,0.00008030219,0.00002958353,0.00004774392,0.0003770848,0.00000811657,0.002739604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001116298,"threshold_uncertainty_score":0.00373441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05397694949200889,"score_gpt":0.3147761662077136,"score_spread":0.2607992167157048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}