{"id":"W4410076578","doi":"10.1007/s40265-025-02183-z","title":"Differentiating IL-23 Inhibitors in Crohn’s Disease","year":2025,"lang":"en","type":"review","venue":"Drugs","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"","keywords":"Medicine; Crohn's disease; Pharmacotherapy; Interleukin 23; Crohn disease; Disease; Internal medicine; Immunology; Pharmacology; Gastroenterology; Interleukin 17; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001440381,0.0004220778,0.000596868,0.0001753062,0.00005863477,0.00004378658,0.000345739,0.000302993,0.00002438638],"category_scores_gemma":[0.0002276429,0.0003979269,0.0005252216,0.0001572387,0.00004877914,0.000002815466,0.0003389001,0.0002295905,0.00006721654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006485257,"about_ca_system_score_gemma":0.0007071137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004529022,"about_ca_topic_score_gemma":0.00001434882,"domain_scores_codex":[0.9981535,0.0002132761,0.000525236,0.0006051662,0.0001548129,0.0003479733],"domain_scores_gemma":[0.9989309,0.0000286578,0.0001930522,0.0006259604,0.00003634993,0.0001850323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006508376,0.0001748738,0.0008853777,0.04258092,0.0001661488,0.0007158982,0.00005608335,0.00000385382,0.00001003939,0.0001473361,0.006559761,0.9486346],"study_design_scores_gemma":[0.0003122385,0.000005747716,0.003117191,0.009317199,0.0003434396,0.000001021234,0.0000172796,0.000003995944,0.000008289479,0.00003304834,0.9862558,0.0005847541],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002873803,0.9942099,0.000006797033,0.000008140047,0.0004360586,0.0007049588,0.0002879179,0.00002388226,0.001448538],"genre_scores_gemma":[0.000891634,0.9938475,0.00002022581,0.00008280679,0.000423183,0.0002886777,0.001679556,0.00005853008,0.002707817],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.979696,"threshold_uncertainty_score":0.9998472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009250379546394055,"score_gpt":0.2783835885818696,"score_spread":0.2691332090354756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}