{"id":"W4410080762","doi":"10.1016/s1470-2045(25)00140-8","title":"Zanidatamab plus palbociclib and fulvestrant in previously treated patients with hormone receptor-positive, HER2-positive metastatic breast cancer: primary results from a two-part, multicentre, single-arm, phase 2a study","year":2025,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre; Health Sciences Centre; Ottawa Hospital; Jewish General Hospital","funders":"Jazz Pharmaceuticals; Pfizer","keywords":"Fulvestrant; Palbociclib; Metastatic breast cancer; Medicine; Oncology; Internal medicine; Cancer; Breast cancer; Hormone receptor; Gynecology; Estrogen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001589808,0.001367595,0.002576914,0.000470708,0.0002826494,0.001159184,0.0008347275,0.0008807203,0.002438888],"category_scores_gemma":[0.0009565682,0.0006055785,0.001941964,0.0006123369,0.000778208,0.00120802,0.0003733234,0.002619468,0.0007454481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001102861,"about_ca_system_score_gemma":0.001064625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001552186,"about_ca_topic_score_gemma":0.005843345,"domain_scores_codex":[0.9995765,0.0001928828,0.00002205707,0.00006417036,0.00004813321,0.00009622811],"domain_scores_gemma":[0.9995245,0.0000887209,0.0001233646,0.00004553396,0.00002166088,0.0001963267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8825015,0.01259861,0.006660733,0.0009098163,0.003929005,0.0001247347,0.0001526725,0.002151495,0.01233376,0.0001684318,0.002181694,0.07628757],"study_design_scores_gemma":[0.80143,0.1585332,0.03272297,0.0000592939,0.002149723,0.0002177997,0.00009988957,0.001075675,0.001054248,0.0002420305,0.002370648,0.00004461054],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919868,0.004837388,0.0002289843,0.0004015083,0.000149413,0.0004796426,0.0006938609,0.00005201572,0.00117049],"genre_scores_gemma":[0.990119,0.00410135,0.0006884631,0.0007612765,0.0001688042,0.0005050585,0.001694238,0.00002705905,0.001934744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002576914,"threshold_uncertainty_score":0.008407772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02242860463022142,"score_gpt":0.3244790213498309,"score_spread":0.3020504167196095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}