{"id":"W4410083423","doi":"10.1016/j.xhgg.2025.100448","title":"Aortic valve-specific genes dysregulated in calcific aortic valve stenosis as potential biomarkers and therapeutic targets","year":2025,"lang":"en","type":"article","venue":"Human Genetics and Genomics Advances","topic":"Cardiac Valve Diseases and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"Canadian Institutes of Health Research; Université Laval; Fondation Institut Universitaire de Cardiologie et de Pneumologie de Québec; Heart and Stroke Foundation of Canada","keywords":"Cardiology; Stenosis; Internal medicine; Aortic valve; Medicine; Aortic valve stenosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002491009,0.0002054386,0.0003418807,0.0006326577,0.0001272699,0.0004264781,0.0001315916,0.0002502342,0.0005421692],"category_scores_gemma":[0.0002830369,0.0000960762,0.0001617163,0.0006194701,0.0002569868,0.0001000193,0.0001417405,0.0002576004,0.0001064941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001396763,"about_ca_system_score_gemma":0.0001703072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003215929,"about_ca_topic_score_gemma":0.0006141994,"domain_scores_codex":[0.9998794,0.000026657,0.000009355684,0.00003615339,0.00003002271,0.00001843174],"domain_scores_gemma":[0.9998249,0.00006303356,0.00006114325,0.000008669277,0.00001547322,0.00002670173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00210087,0.0001277079,0.1645623,0.0004809252,0.0001714983,0.0009650351,0.0002191469,0.0008289128,0.7929591,0.0004034768,0.000466884,0.03671413],"study_design_scores_gemma":[0.00006344851,0.0005222634,0.9313787,0.00005935285,0.0002415112,0.001708017,0.0002657918,0.0023402,0.05886473,0.000680176,0.003858894,0.00001678595],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896449,0.00755992,0.001121574,0.0001847366,0.00003348792,0.00001865549,0.0006582708,0.00002875765,0.0007495961],"genre_scores_gemma":[0.9933029,0.00213133,0.003144437,0.0001573566,0.0000311019,0.00002538127,0.0006615902,0.000007304341,0.0005385547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006326577,"threshold_uncertainty_score":0.00181371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01229930478866974,"score_gpt":0.3108377149739173,"score_spread":0.2985384101852475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}