{"id":"W4410088518","doi":"10.1681/asn.0000000718","title":"Genome-Wide Association Study of Quantitative Kidney Function in 52,531 Individuals with Diabetes Identifies Five Diabetes-Specific Loci","year":2025,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Birth, Development, and Health","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Nutrition, Metabolism and Diabetes; SickKids Foundation; Hospital for Sick Children","funders":"National Heart, Lung, and Blood Institute; Medical Research Council; Perelman School of Medicine, University of Pennsylvania; Genentech; Sigrid Juséliuksen Säätiö; Samfundet Folkhälsan; University of Pennsylvania; Novo Nordisk; Novo Nordisk Fonden; Queen's University Belfast; Regeneron Pharmaceuticals; National Institutes of Health; Department for the Economy; Queen's University; Kidney Research UK; Science Foundation Ireland; UK Research and Innovation; Folkhälsanin Tutkimussäätiö; UCD Foundation; Wilhelm och Else Stockmanns Stiftelse; Gilead Sciences; American Society of Nephrology; American Diabetes Association; National Institute of Diabetes and Digestive and Kidney Diseases; Sanofi; Pfizer","keywords":"Diabetes mellitus; Genome-wide association study; Type 2 diabetes; Population; Medicine; Renal function; Kidney disease; Single-nucleotide polymorphism; Albuminuria; Internal medicine; Candidate gene; Glycated hemoglobin; Biology; Genetics; Endocrinology; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002739094,0.000675489,0.001115136,0.00111277,0.0006298849,0.0009976432,0.0007006307,0.0005195353,0.002490788],"category_scores_gemma":[0.00373754,0.0003867229,0.003458238,0.002889074,0.0003624294,0.0002794141,0.0006457249,0.0007429548,0.0002185682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000374097,"about_ca_system_score_gemma":0.0005001723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01099057,"about_ca_topic_score_gemma":0.0120092,"domain_scores_codex":[0.9977017,0.0006448139,0.0002512454,0.0009299729,0.0002910157,0.0001812892],"domain_scores_gemma":[0.9980761,0.0007759021,0.0004502953,0.0003868471,0.0001669287,0.0001439407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001237768,0.00002758509,0.9711603,0.0001753426,0.0165848,0.0003259303,0.00007444679,0.0004895542,0.002715329,0.0001629144,0.0007786819,0.006267259],"study_design_scores_gemma":[0.0002484506,0.00014561,0.9850485,0.00005987905,0.01069654,0.0005447512,0.00008093796,0.001071584,0.000777365,0.0002627372,0.001046995,0.00001670243],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811184,0.008730492,0.004232154,0.0002808166,0.00007875609,0.00003587445,0.004510048,0.0001205161,0.0008929448],"genre_scores_gemma":[0.997025,0.0005858974,0.0009518918,0.00006924232,0.00001748883,0.0000245949,0.001084239,0.00001404127,0.0002277416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01099057,"threshold_uncertainty_score":0.02185315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0172916945942483,"score_gpt":0.2857595746892908,"score_spread":0.2684678800950425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}