{"id":"W4410089062","doi":"10.1101/2025.05.02.651971","title":"mimicDetector: a pipeline for protein motif mimicry detection in host-pathogen systems","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Mimicry; Motif (music); Host (biology); Pathogen; Biology; Molecular mimicry; Microbiology; Ecology; Genetics; Art; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001474274,0.002630131,0.001661849,0.0016361,0.0008512269,0.001951289,0.002287099,0.00127567,0.02019759],"category_scores_gemma":[0.003142784,0.001386465,0.002027725,0.0008787003,0.0005341422,0.002011251,0.002456944,0.001778894,0.01015159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008944865,"about_ca_system_score_gemma":0.002046827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001701878,"about_ca_topic_score_gemma":0.002509987,"domain_scores_codex":[0.9992427,0.0001137587,0.0000550108,0.0002803797,0.0002126647,0.00009550755],"domain_scores_gemma":[0.9994056,0.0002651753,0.00006828827,0.00009526076,0.00009001372,0.00007566178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00471832,0.000609583,0.01511449,0.006988827,0.001670126,0.002123108,0.001070166,0.0477301,0.285608,0.02034513,0.2790083,0.3350139],"study_design_scores_gemma":[0.0007056834,0.0006105038,0.006616502,0.0002147821,0.000301589,0.001402476,0.0002482458,0.6347501,0.1819953,0.0268937,0.1458509,0.0004102455],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.03016517,0.0008800275,0.4805574,0.0003056072,0.0001806246,0.0005538103,0.01710157,0.4667599,0.003495939],"genre_scores_gemma":[0.1847296,0.0008732975,0.7201034,0.0005819882,0.00008927461,0.001703896,0.05149895,0.03349856,0.006921013],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.02019759,"threshold_uncertainty_score":0.06756771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009875059324610443,"score_gpt":0.2141470942118529,"score_spread":0.2042720348872424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}