{"id":"W4410090828","doi":"10.1101/2025.05.01.25326429","title":"Genetic and Epigenetic Dysregulation of CR1 is Associated with Catastrophic Antiphospholipid Syndrome (CAPS)","year":2025,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Alexion Pharmaceuticals; American Society of Hematology; U.S. Department of Defense","keywords":"Catastrophic antiphospholipid syndrome; Epigenetics; Antiphospholipid syndrome; Immune dysregulation; Medicine; Genetics; Biology; Gene; Internal medicine; Disease; Thrombosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001326686,0.0003439698,0.0001775891,0.0004801944,0.000143874,0.0002104323,0.0001677496,0.0002587499,0.001918604],"category_scores_gemma":[0.0003846701,0.00009606878,0.0001714808,0.0003401455,0.0001765789,0.00007612432,0.0002323505,0.000241793,0.0001657907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001474179,"about_ca_system_score_gemma":0.0001051464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009114802,"about_ca_topic_score_gemma":0.0008902831,"domain_scores_codex":[0.9998104,0.00002202219,0.00001716549,0.00007210227,0.00005571409,0.00002266528],"domain_scores_gemma":[0.9998084,0.00002991503,0.0001095991,0.00001067678,0.00001980267,0.00002157528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001025227,0.00004925458,0.1160164,0.000187731,0.0002121479,0.00275598,0.0001381761,0.0004223851,0.8571813,0.0003900397,0.0005603437,0.02106106],"study_design_scores_gemma":[0.00005661475,0.0004381569,0.8088341,0.00005773204,0.0002902934,0.02087763,0.0001440808,0.002273265,0.1618002,0.0004681036,0.004733928,0.0000259219],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957729,0.0009074879,0.001641579,0.00008330941,0.00001427533,0.00001181708,0.0007649996,0.00005183016,0.0007517688],"genre_scores_gemma":[0.9982958,0.0002490353,0.0006505274,0.00004353497,0.000009001229,0.0000072363,0.0003241172,0.00000779972,0.0004128231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001918604,"threshold_uncertainty_score":0.006418407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01970461495249717,"score_gpt":0.2766399582619362,"score_spread":0.256935343309439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}