{"id":"W4410092913","doi":"10.14814/phy2.70339","title":"Dual inhibition of <scp>TGFβ</scp> and <scp>PDGF</scp> improves <scp>RV</scp> remodeling and function in response to <scp>RV</scp> pressure or volume‐loading","year":2025,"lang":"en","type":"article","venue":"Physiological Reports","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Hospital for Sick Children; Muscular Dystrophy Canada; University of Toronto","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Platelet-derived growth factor receptor; Muscle hypertrophy; Fibrosis; Transforming growth factor; Growth factor; Signal transduction; Endocrinology; Internal medicine; Medicine; Chemistry; Biology; Cancer research; Cell biology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001918488,0.0004773844,0.0004493021,0.0001934412,0.000129062,0.0003033066,0.0001983912,0.0002475319,0.001336174],"category_scores_gemma":[0.000119076,0.0001326151,0.0003317862,0.0001209883,0.0003342467,0.0002969531,0.0001505433,0.001323109,0.0003232965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001278182,"about_ca_system_score_gemma":0.0003111351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002719072,"about_ca_topic_score_gemma":0.0005715049,"domain_scores_codex":[0.99985,0.00002427916,0.00001645338,0.00002656443,0.00004087538,0.00004173145],"domain_scores_gemma":[0.9998953,0.00001388696,0.00003470833,0.000009082776,0.000009704648,0.00003738623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001401537,0.0003326035,0.0002759942,0.0001502483,0.00002972667,0.00006781601,0.00001680374,0.00009784094,0.9899579,0.0001223045,0.0001762024,0.00737113],"study_design_scores_gemma":[0.0003586669,0.006540673,0.007160242,0.00002036172,0.0001396491,0.0005233529,0.00005585391,0.001330587,0.9797511,0.0001074765,0.003999843,0.00001216478],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907007,0.003649077,0.003071192,0.0002841933,0.0001417752,0.00005681708,0.0002451516,0.0001782996,0.00167281],"genre_scores_gemma":[0.9922128,0.002772684,0.002429572,0.0001543938,0.00006793484,0.0000836131,0.0003251438,0.00002772429,0.001926083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001336174,"threshold_uncertainty_score":0.004469991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0284901172388386,"score_gpt":0.2954264272998361,"score_spread":0.2669363100609975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}