{"id":"W4410095639","doi":"10.1021/acscatal.6c02684","title":"Double Deoxygenative Coupling of Carboxylic Acids and Alcohols","year":2025,"lang":"en","type":"preprint","venue":"ACS Catalysis","topic":"Asymmetric Hydrogenation and Catalysis","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Genmab; Janssen Pharmaceuticals; Genentech; Bristol-Myers Squibb Canada; Princeton University; National Institute of General Medical Sciences; Merck; National Institutes of Health; Pfizer; Bristol-Myers Squibb","keywords":"Coupling (piping); Chemistry; Carboxylic acid; Organic chemistry; Materials science; Composite material","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001894517,0.0004835742,0.0001819867,0.0002281281,0.0001290965,0.0002072646,0.0003260806,0.000272254,0.003323301],"category_scores_gemma":[0.0001656995,0.0001702181,0.0001990992,0.0001585591,0.0001880305,0.0004361333,0.0004721468,0.0006714362,0.0009376545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002211206,"about_ca_system_score_gemma":0.0001680936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002806569,"about_ca_topic_score_gemma":0.0005927258,"domain_scores_codex":[0.9998496,0.000009005675,0.000007627456,0.00005201188,0.00003198442,0.0000498135],"domain_scores_gemma":[0.9999232,0.00001201556,0.00001919006,0.00001693325,0.00001153036,0.00001710941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005363211,0.00001637124,0.0001068887,0.00008555401,0.000009481972,0.0002387411,0.00007199687,0.00016756,0.9899411,0.001346865,0.0002821123,0.00767994],"study_design_scores_gemma":[0.000003380215,0.00006638118,0.000189046,0.000002396911,0.000003513748,0.00014164,0.000009640004,0.0002051736,0.9954758,0.0000872426,0.003811015,0.000004672297],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9243501,0.00356557,0.04788567,0.000392238,0.000307921,0.0001027134,0.0005817545,0.0006467715,0.02216722],"genre_scores_gemma":[0.9788386,0.001590246,0.01139416,0.00009834721,0.00003142088,0.00003179699,0.0003612167,0.00007468066,0.007579443],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003323301,"threshold_uncertainty_score":0.01111752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0194427100846265,"score_gpt":0.2780028582071929,"score_spread":0.2585601481225664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}