{"id":"W4410095639","doi":"10.1021/acscatal.6c02684","title":"Double Deoxygenative Coupling of Carboxylic Acids and Alcohols","year":2025,"lang":"en","type":"preprint","venue":"ACS Catalysis","topic":"Asymmetric Hydrogenation and Catalysis","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Genmab; Janssen Pharmaceuticals; Genentech; Bristol-Myers Squibb Canada; Princeton University; National Institute of General Medical Sciences; Merck; National Institutes of Health; Pfizer; Bristol-Myers Squibb","keywords":"Coupling (piping); Chemistry; Carboxylic acid; Organic chemistry; Materials science; Composite material","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002937742,0.0004101222,0.0009043608,0.0006202028,0.0001034189,0.00006305963,0.0006123129,0.0005444351,0.0002871056],"category_scores_gemma":[0.0001621224,0.0004267021,0.0003828903,0.001003836,0.000141679,0.00007569441,0.001230504,0.000549667,0.00001167681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001637281,"about_ca_system_score_gemma":0.0002305924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000702153,"about_ca_topic_score_gemma":0.00004279344,"domain_scores_codex":[0.9976934,0.0000088705,0.0006936403,0.0008047479,0.0005151022,0.0002842024],"domain_scores_gemma":[0.9976835,0.0001745365,0.0005570079,0.001104911,0.0003489119,0.0001311191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001682677,0.003806453,0.107541,0.02895229,0.08964782,0.0002620016,0.03764885,0.0653375,0.4069776,0.009281406,0.006192433,0.2426701],"study_design_scores_gemma":[0.001168676,0.00000765827,0.000272313,0.0002446531,0.002635222,0.000003490418,0.0009296543,0.0065621,0.9853213,0.0003640956,0.001777632,0.0007131448],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.952924,0.004277485,0.0005129837,0.0001537059,0.0001104609,0.0001807266,0.0005030741,0.0001276152,0.04121],"genre_scores_gemma":[0.9922245,0.0006998064,0.0002103013,0.00004085192,0.00007426157,0.000110072,0.001776517,0.00002789962,0.004835852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5783438,"threshold_uncertainty_score":0.9998185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0194427100846265,"score_gpt":0.2780028582071929,"score_spread":0.2585601481225664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}