{"id":"W4410103279","doi":"10.1111/imm.13922","title":"Human Alveolar Macrophages Detect SARS‐CoV‐2 Envelope Protein Through TLR2 and TLR4 and Secrete Cytokines in Response","year":2025,"lang":"en","type":"article","venue":"Immunology","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Science Foundation Ireland; Health Research Board; Wellcome Trust; Canadian Institute for Theoretical Astrophysics","keywords":"TLR2; Immune system; Inflammation; Secretion; Immunology; Cytokine; TLR4; Tumor necrosis factor alpha; Biology; Innate immune system; Proinflammatory cytokine; Toll-like receptor; Lung; Medicine; Internal medicine; Endocrinology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000314686,0.0003087269,0.0002368937,0.0003137262,0.0002020366,0.0003081476,0.0001223176,0.0003765087,0.004223839],"category_scores_gemma":[0.0003318283,0.0001361965,0.0002543899,0.0001707537,0.0001470694,0.0002096585,0.0003664302,0.0002905525,0.001892459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009986135,"about_ca_system_score_gemma":0.0001459042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003223326,"about_ca_topic_score_gemma":0.0003380664,"domain_scores_codex":[0.999745,0.00006808778,0.000024012,0.00004492977,0.00005507747,0.00006306201],"domain_scores_gemma":[0.9998364,0.00002797943,0.00004562278,0.00001599207,0.00005054298,0.00002340692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008517597,0.0002514248,0.03746696,0.0002088253,0.00004090287,0.0005143663,0.0002990468,0.00007239667,0.9466147,0.0001038266,0.0006901419,0.01288564],"study_design_scores_gemma":[0.0003113132,0.007022884,0.3803951,0.000206861,0.0001462771,0.005742756,0.002192374,0.0009166423,0.5716114,0.0007696981,0.03063446,0.00005024785],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890293,0.003289406,0.001661599,0.0002563512,0.0000569919,0.0001288988,0.0006702382,0.00005518416,0.004852091],"genre_scores_gemma":[0.9909188,0.001614676,0.001449054,0.0004241895,0.00008169759,0.0001513255,0.001057228,0.000005201106,0.004297839],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004223839,"threshold_uncertainty_score":0.01413018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03674279939999583,"score_gpt":0.4200558958724774,"score_spread":0.3833130964724816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}