{"id":"W4410112240","doi":"10.1371/journal.ppat.1012686","title":"A surface lipoprotein on Pasteurella multocida binds complement factor I to promote immune evasion","year":2025,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Microbial infections and disease research","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada","keywords":"Complement system; Immune system; C3-convertase; Microbiology; Biology; Factor H; Innate immune system; Pasteurella multocida; Complement control protein; Pathogen; Classical complement pathway; Protein subunit; CD46; Effector; Complement factor I; Alternative complement pathway; Immunology; Bacteria; Gene; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001930123,0.0002323728,0.0003062266,0.00022153,0.0003795032,0.00003798774,0.0002207505,0.000177188,0.001909866],"category_scores_gemma":[0.0001203403,0.000200842,0.0001527452,0.0004150783,0.00005844313,0.00002902212,0.0002339091,0.0003123069,0.002669834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001243155,"about_ca_system_score_gemma":0.0001107609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002363977,"about_ca_topic_score_gemma":0.00005123658,"domain_scores_codex":[0.9983652,0.0002436066,0.0003277672,0.000462914,0.00007444094,0.0005260541],"domain_scores_gemma":[0.9991295,0.00008083728,0.00005525652,0.0005172361,0.0001481857,0.0000689755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002134246,0.000737967,0.0005684308,0.00005461842,0.0001885358,0.000008810023,0.000220466,0.00004017498,0.9874725,0.0003557165,0.002185704,0.007953682],"study_design_scores_gemma":[0.001287921,0.0005784535,0.005313565,0.0002400275,0.000048084,0.000004284331,0.00008566698,0.00002677608,0.9341449,0.00004306275,0.05796283,0.0002644365],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946265,0.0005804782,0.000179239,0.000665172,0.0003190814,0.001508025,0.0005213781,0.000115293,0.001484888],"genre_scores_gemma":[0.9932601,0.00003733748,0.0001947163,0.0002274537,0.00002377088,0.00009688459,0.0001435592,0.00002209876,0.005994121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05577713,"threshold_uncertainty_score":0.9990025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03219800864703127,"score_gpt":0.2995533146590404,"score_spread":0.2673553060120092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}