{"id":"W4410118567","doi":"10.1007/978-3-031-80173-0_4","title":"Nanocarriers for Transportation Across the Blood-Brain Barrier","year":2025,"lang":"en","type":"book-chapter","venue":"","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Nanocarriers; Blood–brain barrier; Computer science; Nanotechnology; Neuroscience; Materials science; Psychology; Drug delivery; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001977105,0.0005801147,0.0004890327,0.0005135564,0.0003051763,0.0009457241,0.0005827775,0.0009892606,0.005644646],"category_scores_gemma":[0.0001832315,0.0002312874,0.0003622121,0.0004917605,0.0003365128,0.001523961,0.0007115063,0.001255477,0.003548091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007834182,"about_ca_system_score_gemma":0.0003265622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006276673,"about_ca_topic_score_gemma":0.001172763,"domain_scores_codex":[0.9999061,0.00001091484,0.000003904595,0.00002007767,0.00004713659,0.00001186517],"domain_scores_gemma":[0.9999638,0.000017893,0.00000425466,0.00000260953,0.000007977595,0.000003466597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000161296,0.00009857944,0.00004947666,0.001961395,0.00005384647,0.0004289256,0.0003045367,0.00307825,0.2853564,0.2111749,0.06968532,0.4276471],"study_design_scores_gemma":[0.00002128766,0.0001020774,0.0001093451,0.0003137613,0.00003060054,0.0008534339,0.00006899542,0.003392928,0.0836501,0.02740302,0.8840168,0.0000376063],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01350312,0.677756,0.135491,0.004630925,0.005359119,0.0001965436,0.0004165794,0.000700806,0.1619458],"genre_scores_gemma":[0.06950349,0.4217709,0.0679737,0.002256996,0.001007558,0.0003504043,0.0003507433,0.0003141469,0.4364721],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005644646,"threshold_uncertainty_score":0.01888323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006730717763582602,"score_gpt":0.255250481989487,"score_spread":0.2485197642259044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}