{"id":"W4410118665","doi":"10.1038/s41467-025-59430-w","title":"A highly conserved neuronal microexon in DAAM1 controls actin dynamics, RHOA/ROCK signaling, and memory formation","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Advanced Fluorescence Microscopy Techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Agencia Estatal de Investigación; Canadian Institutes of Health Research; University of Toronto; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institutes of Health; Generalitat de Catalunya; European Commission; Ministerio de Ciencia e Innovación; Centres de Recerca de Catalunya","keywords":"RHOA; Actin; Cell biology; Dynamics (music); Actin cytoskeleton; Signal transduction; Biology; Cytoskeleton; Genetics; Physics; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001553851,0.0001281191,0.000135949,0.0001021257,0.000140265,0.00002986976,0.0005215445,0.0003107429,0.000001492956],"category_scores_gemma":[0.0002586581,0.0001390414,0.00003848144,0.0001499518,0.0001098771,0.00001479477,0.0003574773,0.000539889,0.000001032663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005650137,"about_ca_system_score_gemma":0.00007060251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002297176,"about_ca_topic_score_gemma":0.001186358,"domain_scores_codex":[0.9992159,0.0001318313,0.0002391905,0.0002087391,0.00005179613,0.0001525671],"domain_scores_gemma":[0.9988357,0.00009534915,0.0000986681,0.000830675,0.0001104545,0.00002912774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005826389,0.00006256421,0.002916359,0.0000160772,0.00001334969,3.54796e-7,0.00003091645,0.00001029671,0.991849,0.002237462,0.001699163,0.001106186],"study_design_scores_gemma":[0.00114385,0.00009339438,0.006786482,0.0001261011,0.00002846115,0.00001071334,0.0001971684,0.003066383,0.9490019,0.0006728513,0.03859333,0.0002793345],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9263887,0.02401594,0.03316841,0.0119528,0.000189386,0.001506492,0.00018729,0.0001513035,0.002439667],"genre_scores_gemma":[0.9779432,0.001049155,0.01910322,0.001140347,0.00001184181,0.00007013998,0.0004721238,0.00001184901,0.000198168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05155444,"threshold_uncertainty_score":0.5669945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007218967360044696,"score_gpt":0.2952277438843937,"score_spread":0.288008776524349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}