{"id":"W4410120376","doi":"10.1038/s41586-025-09074-z","title":"Molecular basis of SIFI activity in the integrated stress response","year":2025,"lang":"en","type":"article","venue":"Nature","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute","funders":"","keywords":"Stress (linguistics); Chemistry; Computational biology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001701032,0.00029567,0.0001630068,0.0001370779,0.00014903,0.0003306671,0.0003333849,0.0004365709,0.001287797],"category_scores_gemma":[0.0001395884,0.00009537962,0.0001865709,0.00008619532,0.0003586518,0.0003480265,0.0001857941,0.0004137621,0.0005532744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000446353,"about_ca_system_score_gemma":0.0001351918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002513739,"about_ca_topic_score_gemma":0.0001834245,"domain_scores_codex":[0.9999114,0.000009083944,0.000004627168,0.00002586551,0.00002884125,0.0000200917],"domain_scores_gemma":[0.9998214,0.00003784441,0.00005018277,0.00002681718,0.0000254149,0.0000383841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004699513,0.00000973337,0.0003987762,0.00002357886,0.000003896218,0.0001034322,0.000009674938,0.0002141033,0.9961215,0.001489567,0.00003977888,0.001538848],"study_design_scores_gemma":[0.00001507099,0.0002153874,0.006532258,0.000008067645,0.00000837212,0.0005223249,0.00002533889,0.006612949,0.9823271,0.001556612,0.002168995,0.000007466769],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9722902,0.00278067,0.02106799,0.0002738091,0.00006567797,0.00002115973,0.0001722981,0.0002364359,0.003091719],"genre_scores_gemma":[0.9960747,0.0003621605,0.002366541,0.00004663478,0.00001186772,0.000007589968,0.0001411377,0.000006301427,0.0009830939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001287797,"threshold_uncertainty_score":0.004308105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004903304559939165,"score_gpt":0.2673031126549119,"score_spread":0.2623998080949727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}