{"id":"W4410122593","doi":"10.1096/fj.202401781r","title":"Reduced Palmitoylation of <scp>SQSTM1</scp> /p62 in Huntington Disease Is Associated With Impaired Autophagy","year":2025,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Children's Hospital; University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Royal Society","keywords":"Palmitoylation; Autophagy; Sequestosome 1; Cell biology; Chemistry; ULK1; Flux (metallurgy); Lysosome; Biology; Biochemistry; Apoptosis; Enzyme; Phosphorylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000134,0.0002526346,0.0003521699,0.0003710867,0.0001791858,0.0001859784,0.0001164923,0.0003285144,0.00133998],"category_scores_gemma":[0.0001037175,0.0001388119,0.0002291866,0.0002410891,0.000328982,0.0001565104,0.0001978634,0.0003594766,0.000281214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001756355,"about_ca_system_score_gemma":0.0001272965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006600627,"about_ca_topic_score_gemma":0.0006119848,"domain_scores_codex":[0.9999026,0.00001546311,0.00002204801,0.0000224446,0.00002337424,0.0000140438],"domain_scores_gemma":[0.9998953,0.00001149983,0.00004118652,0.000008285781,0.000008844148,0.00003474705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003602926,0.00003517097,0.0008256087,0.00004660707,0.00002158599,0.0003726733,0.00002300255,0.00004995952,0.9973157,0.00007811165,0.00005249928,0.0008188756],"study_design_scores_gemma":[0.00005683121,0.0006964908,0.05377286,0.00001536688,0.0000806103,0.004906673,0.00006904834,0.001517208,0.9363774,0.0003271187,0.002165461,0.00001499852],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976624,0.0007981256,0.0008149479,0.00005142617,0.00001616335,0.000008222366,0.0002243392,0.00003485022,0.000389472],"genre_scores_gemma":[0.9981952,0.0003529833,0.0004332908,0.00003989935,0.000005995188,0.00001087867,0.0003178665,0.00001061941,0.000633238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00133998,"threshold_uncertainty_score":0.004482627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01141813163559076,"score_gpt":0.2657900464767208,"score_spread":0.2543719148411301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}