{"id":"W4410124125","doi":"10.1038/s41467-025-59560-1","title":"Single-dose replicon RNA Sudan virus vaccine uniformly protects female guinea pigs from disease","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Division of Intramural Research, National Institute of Allergy and Infectious Diseases","keywords":"Replicon; Virology; Vaccination; Outbreak; Virus; Ebola virus; Biology; Alphavirus; Disease; Medicine; Immunology; Gene; Plasmid; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002213404,0.0003768268,0.000335594,0.0002191547,0.00009142004,0.0001771232,0.0001926567,0.0004036412,0.001413365],"category_scores_gemma":[0.0001613921,0.0001358743,0.000187072,0.00007647597,0.0001984699,0.0002272814,0.0001139296,0.0005408332,0.0002932887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001567094,"about_ca_system_score_gemma":0.0001821176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003728392,"about_ca_topic_score_gemma":0.0005527531,"domain_scores_codex":[0.9998722,0.00002541988,0.000007464107,0.00003213588,0.00002292805,0.00003982142],"domain_scores_gemma":[0.9998735,0.00002857236,0.00003358867,0.00001670003,0.00001794453,0.00002959326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000622971,0.0004093457,0.0004504259,0.00004849302,0.00001255295,0.00002587812,0.00001844779,0.000160372,0.9952202,0.00004457781,0.00006867021,0.002917975],"study_design_scores_gemma":[0.0001359893,0.02336889,0.00653656,0.0000242922,0.00003850421,0.0001792342,0.00005256873,0.001190436,0.9664336,0.00005576776,0.001977098,0.00000710189],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970855,0.0005631596,0.001068683,0.00006131849,0.00005534737,0.00007688187,0.0001708147,0.00005027219,0.0008679077],"genre_scores_gemma":[0.9950851,0.0003715406,0.001500112,0.00005598137,0.00001896691,0.00007917258,0.0003354647,0.0000102475,0.002543375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001413365,"threshold_uncertainty_score":0.004728198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03807230636515872,"score_gpt":0.3639876601135938,"score_spread":0.3259153537484351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}