{"id":"W4410126940","doi":"10.63204/4759.2","title":"Activation-pathway transitions in human voltage-gated proton channels revealed by a non-canonical fluorescent amino acid","year":2022,"lang":"en","type":"preprint","venue":"","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"Fluorescence; Proton; Non canonical; Chemistry; Biophysics; Voltage; Physics; Biology; Cell biology; Optics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001160325,0.0001277284,0.00009093151,0.00007773607,0.0000658909,0.0001543871,0.00008781873,0.0002300121,0.0005681958],"category_scores_gemma":[0.0002578695,0.00008061609,0.0001122998,0.0000744114,0.0001657066,0.0001786268,0.0001317591,0.0001954932,0.0001718127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001344107,"about_ca_system_score_gemma":0.00009136696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002248503,"about_ca_topic_score_gemma":0.0001864119,"domain_scores_codex":[0.9999501,0.00001047057,0.000002769312,0.00001815322,0.000009804814,0.00000880622],"domain_scores_gemma":[0.9999287,0.00003130802,0.00001849124,0.000008114903,0.000004411773,0.000008980143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001454398,0.00000781057,0.0008343671,0.00001709881,0.000003377617,0.00009179763,0.0000305251,0.0001844048,0.9968408,0.0001750349,0.0000175496,0.001651789],"study_design_scores_gemma":[0.00001713502,0.0001939849,0.0198592,0.000003216384,0.000007864491,0.0006724923,0.00003379969,0.003829731,0.9738625,0.0004858444,0.001026469,0.000007744425],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968241,0.0001815536,0.00266569,0.00001988862,0.000003614127,0.00000239719,0.00005666136,0.00003632862,0.0002099124],"genre_scores_gemma":[0.9967955,0.0001814514,0.002359956,0.00001444279,0.000003124582,0.000006621159,0.0001185995,0.00001331977,0.0005072097],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005681958,"threshold_uncertainty_score":0.001900733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01594084789549015,"score_gpt":0.2655802407047657,"score_spread":0.2496393928092755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}