{"id":"W4410129529","doi":"10.21203/rs.3.rs-5493661/v1","title":"Psilocybin Mitigates Behavioral Despair and Cognitive Impairment in Treatment-resistant Depression Model using Wistar Kyoto Rats","year":2025,"lang":"en","type":"preprint","venue":"Research Square","topic":"Psychedelics and Drug Studies","field":"Psychology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Mitacs; University of Alberta","keywords":"Psilocybin; Depression (economics); Cognitive impairment; Treatment-resistant depression; Cognition; Psychology; Clinical psychology; Medicine; Psychiatry; Hallucinogen; Major depressive disorder","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009404286,0.0005385136,0.0007327765,0.0008981099,0.0004081221,0.0001510662,0.0002920546,0.0005143658,0.00007718339],"category_scores_gemma":[0.00006774611,0.000476323,0.0001874024,0.0003944699,0.0003830603,0.00006302317,0.001210759,0.001052233,0.00001376644],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007511108,"about_ca_system_score_gemma":0.000551007,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00862077,"about_ca_topic_score_gemma":0.002365754,"domain_scores_codex":[0.9955156,0.0008557565,0.0005497543,0.001356685,0.0006398637,0.001082378],"domain_scores_gemma":[0.9980658,0.0004677124,0.0001265991,0.0006506675,0.0004393055,0.0002498668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0166446,0.01863453,0.7787508,0.004798689,0.002827934,0.003186563,0.09712969,0.006656101,0.00600582,0.002408262,0.00746979,0.05548719],"study_design_scores_gemma":[0.03726882,0.008603454,0.5674837,0.04562469,0.001767758,0.00005987025,0.1288947,0.1389089,0.009864091,0.05299778,0.001559192,0.006967028],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979174,0.01299169,0.0001100491,0.000240327,0.0002287828,0.002671314,0.001243897,0.00006608762,0.003273824],"genre_scores_gemma":[0.9954989,0.0006947347,0.0005231489,0.00002481443,0.00007611764,0.001349203,0.0001681103,0.00004627448,0.001618717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2112671,"threshold_uncertainty_score":0.9997689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1813391035934671,"score_gpt":0.5066027463610822,"score_spread":0.325263642767615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}